基于数据挖掘探析吕光荣教授运用中医药治疗恶性肿瘤的用药规律  

Exploring the Medication Patterns of Professor Lv Guangrong in Treating Malignant Tumors with Chinese Medicine Based on Data Mining

作　　者：姜琳 徐煜 杨志君 李彭辉 吕光荣 董有康 JIANG Lin;XU Yu;YANG Zhijun;LI Penghui;LV Guangrong;DONG Youkang(Second Clinical Medical College,Yunnan University of Chinese Medicine,Kunming 650051,China;Famous Doctor Clinic,The First Affiliated Hospital of Yunnan University of Chinese Medicine,Kunming 650021,China;Department of Preventive Treatment of Diseases,The First Affiliated Hospital of Yunnan University of Chinese Medicine,Kunming 650021,China;Department of Rehabilitation,Lincang Municipal Hospital of Chinese Medicine,Lincang 677000,China)

机构地区：[1]云南中医药大学第二临床医学院,云南昆明650051 [2]云南中医药大学第一附属医院名医馆,云南昆明650021 [3]云南中医药大学第一附属医院治未病科,云南昆明650021 [4]临沧市中医医院康复医学科,云南临沧677000

出　　处：《云南中医药大学学报》2025年第2期69-77,共9页Journal of Yunnan University of Chinese Medicine

基　　金：第七批全国老中医药专家学术经验继承项目(国中医药办人教函[2021]272号);云南省中青年学术和技术带头人后备人才(202105AC160052);云南省兴滇英才支持计划医疗卫生人才(原名医);云南省教育厅科学研究基金项目(2024Y415)。

摘　　要：目的采用数据挖掘技术对吕光荣教授在中医药治疗恶性肿瘤方面的用药规律进行深入分析。方法收集吕光荣教授在云南省中医医院门诊诊治的所有恶性肿瘤患者的临床资料。将所得资料录入至Microsoft Excel建立处方数据库,应用R4.3.2软件药物数据进行了频率分析,以及共现分析和关联规则探索,对频繁出现的药物进行聚类以及相关性分析。结果纳入符合标准的方剂254首,涉及178味中药,使用频次最高的药物为白术(229次),四气以温性(39.89%)为主,五味以甘味居多(31.64%),肝经频次最高(20.14%),共现次数最高的是白术-黄芪(188次),三项关联规则支持度最高为陈皮,黄芪=>白术,最佳聚类数为5类,有3个药物组合的相关性较高。结论吕光荣教授治疗恶性肿瘤,重在补虚扶正、行气活血,以白术、黄芪等药物为主,调理气血,增强正气,以阻止病邪侵袭,彰显中医辨证施治之精髓。Objective To analyse Professor Lv Guangrong’s medication patterns in treating malignant tumours with Chinese medicine using data mining technology.Methods Clinical data of all malignant tumour patients treated by Professor Lv Guangrong in the outpatient department of Yunnan Province Chinese Medicine Hospital were collected.We conducted frequency analysis,co-occurrence analysis,and association rule exploration of the drug data using R4.3.2 software,which included clustering and correlation analysis of frequently used drugs.Results We included 254 prescriptions that met the criteria,involving 178 Chinese herbs in the results.The most frequently used herb was Bai Zhu(229 times),with warm properties(39.89%)being the predominant nature and sweet flavour(31.64%)being the most common taste.The liver meridian had the highest frequency(20.14%).The highest co-occurrence was Bai Zhu-Huang Qi(188 times).The three association rules with the highest support were Chen Pi,Huang Qi=>Bai Zhu,with the optimal number of clusters being five,and three combinations of herbs showing high correlation.Conclusion In treating malignant tumours,Professor Lv Guangrong focuses on nourishing deficiency,supporting righteousness,activating Qi,and promoting blood circulation,mainly using herbs such as Bai Zhu and Huang Qi to regulate Qi and blood,enhance vital energy,and prevent the invasion of pathogenic factors,exemplifying the essence of syndrome differentiation and treatment in Chinese medicine.

关 键 词：恶性肿瘤 癌症 中医药 数据挖掘 用药规律 名老中医 R语言 可视化 

分 类 号：R730.52[医药卫生—肿瘤]