新辅助治疗在微创食管癌手术的安全性分析  

Analysis on the safety of neoadjuvant therapy in minimally invasive esophageal cancer

作　　者：王涛[1] 詹必成 刘建[1] 陈剑[1] WANG Tao;ZHAN Bicheng;LIU Jian;CHEN Jian(Department of thoracic and cardiac surgery,Anqing Medical Center of Anhui Medical University,Anqing Anhui 246000,China)

机构地区：[1]安徽医科大学安庆医学中心胸心外科,安徽安庆246000

出　　处：《云南医药》2025年第2期5-8,共4页Medicine and Pharmacy of Yunnan

基　　金：安徽医科大学校研基金项目(2020xkj240)。

摘　　要：目的探讨新辅助治疗联合MIE的安全性。方法选取本科室2021年11月-2023年11月行MIE患者的108例为研究对象,其中新辅助治疗联合微创手术治疗(nT+MIE)组39例,单纯微创手术(MIE)组69例,收集2组围手术期数据和术后并发症情况,观察新辅助治疗对微创食管癌手术安全性的影响。结果nT+MIE组较单纯MIE组术中出血少、术后病灶最大径小、胸管留置天数多、纵膈引流管留置天数少,差异有统计学意义(P<0.05);术后并发症方面,nT+MIE组较单纯MIE组吻合口瘘发生率低、肺部感染发生率高,差异有统计学意义(P<0.05);在手术时长、清扫淋巴结数量、术后住院天数以及其它术后并发症方面2组差异均无统计学意义(P>0.05)。结论新辅助治疗联合微创食管癌手术总体安全可靠,不延长手术时间,术中出血更少,且未明显增加术后并发症。Objective To investigate the safety of neoadjuvant therapy combined with minimally invasive esophagectomy(MIE)for esophageal cancer.Methods A total of 108 patients who underwent MIE from November 2021 to November 2023 in our department were selected as the research subjects,including 39 cases in the neoadjuvant therapy combined with minimally invasive surgery(nT+MIE)group and 69 cases received MIE alone group.The perioperative data and postoperative complications of two groups were collected to observe the effect of neoadjuvant therapy on the safety of minimally invasive esophageal cancer surgery.Results Compared with MIE alone group,nT+MIE group had less intraoperative bleeding,smaller maximum diameter of postoperative lesions,longer thoracic tube placement days and shorter mediastinal drainage tube placement days,with statistically significant differences(P≤0.05).In terms of postoperative complications,nT+MIE group had a lower incidence of anastomotic fistula leakage and a higher incidence of pulmonary infection compared with MIE group,with statistically significant differences(P≤0.05).There were no statistically significant differences between the two groups in terms of operation duration,number of lymph nodes dissected,postoperative hospital stay and other postoperative complications(P>0.05).Conclusions Neoadjuvant therapy combined with minimally invasive esophagectomy is generally safe and reliable,with no longer operation time,less intraoperative bleeding,and no significantly increase in postoperative complications.

关 键 词：食管癌 微创食管癌手术 新辅助治疗 术后并发症 

分 类 号：R735.1[医药卫生—肿瘤]