难治性顽固性慢性偏头痛合并卵圆孔未闭的研究进展  

Research progress of intractable chronic migraine complicated with patent foramen ovale

作　　者：段艳花 盛雪汉(综述) 周建丽(审校) DUAN Yanhua;SHENG Xuehan;ZHOU Jianli(Department of Cardiology,Yunnan Fuwai Cardiovascular Hospital,Kunming Yunnan 650032,China;Department of Coronary heart disease and neurology,Yunnan Fuwai Cardiovascular Hospital,Kunming Yunnan 650032,China)

机构地区：[1]云南省阜外心血管病医院心内科,云南昆明650032 [2]云南省阜外心血管病医院冠心病与神经内科,云南昆明650032

出　　处：《云南医药》2025年第2期63-66,共4页Medicine and Pharmacy of Yunnan

基　　金：云南省重大科技立项项目(202302AA310045)。

摘　　要：偏头痛是神经内科门诊最常见疾病之一,也是就诊人数最多的致残性疾病。其主要临床症状为:中重度、单侧、搏动性疼痛,疼痛持续时间一般在4~72h,日常活动(上坡、爬楼)可加重,常伴恶心或呕吐、畏光或畏声等伴随症状,头痛时处于安静环境中或休息后可自行缓解。有研究显示偏头痛多与环境、遗传、神经递质异常分泌等有关,但是直接的临床诱因还不明确[1]。目前研究表明偏头痛与PFO存在很高的相关性[2],且PFO又与CCI关系密切。越来越多的研究发现偏头痛患者常合并PFO和(或)CCI。故三者的发病机制、治疗方法等引起了广大学者的关注。本综述简单阐述了三者目前的研究进展及难治、顽固性偏头痛和CCI患者治疗的循证依据。Migraine is one of the most common diseases in neurology outpatient department,and it is also the most disabling disease.Its main clinical symptoms are:moderate to severe,unilateral,throbbing pain,the pain duration is generally four to 72 hours,daily activities(upslope,climbing stairs)can be aggravated,often accompanied by nausea or vomiting,photophobia or fear of sound and other accompanying symptoms,headache in a quiet environment or after rest can be alleviated by itself.Studies have shown that migraine is mostly related to environmental,genetic,and abnormal neurotransmitter secretion,but the direct clinical cause is not clear.Current studies have shown a high correlation between migraine and PFO,and PFO is closely related to CCI.More and more studies have found that migraine patients often have PFO and/or CCI.Therefore,the pathogenesis and treatment of the three have attracted the attention of many scholars.This review briefly describes the current research progress of the three and the evidence-based basis for the treatment of refractory migraine and CCI patients.

关 键 词：顽固难治 偏头痛 卵圆孔未闭 隐源性脑梗死 治疗 

分 类 号：R747.2[医药卫生—神经病学与精神病学]