ProGRP、IGF-1和E-cadherin在胃癌中的表达及与预后的关系  

The expression of ProGRP,IGF-1 and E-cadherin in gastric cancer and their relationship with prognosis

作　　者：张玉芝 郑雯菁 苏芳 刘飞 ZHANG Yuzhi;ZHENG Wenjng;SU Fang;LIU Fei(Department of Laboratory Medicine,Affliated Hospital of Shandong Second Medical University,Weifang 261031,China;Shandong Second Medical University)

机构地区：[1]山东第二医科大学附属医院检验科,山东潍坊261031 [2]山东第二医科大学

出　　处：《山东第二医科大学学报》2025年第1期24-27,55,共5页Journal of Shandong Second Medical University

基　　金：潍坊市卫生健康委员会科研项目(项目编号:WFWSJK-2023-226)。

摘　　要：目的 探讨胃泌素释放肽前体(ProGRP)、胰岛素样生长因子1(IGF-1)和上皮细胞钙黏素(E-cadherin)在胃癌中的表达及与预后的关系。方法 选取2021年1月~2022年1月本院收治的80例胃癌患者(病例组)及45例健康体检者(对照组)为研究对象,病例组又分为预后良好组和预后不良组。比较两组患者各指标水平的差异,及80例患者入院时和术后7 d血清ProGRP、IGF-1和E-cadherin水平,同时收集病例组预后良好组和预后不良组患者的一般资料,绘制受试者工作特征(ROC)曲线,评估ProGRP、IGF-1、E-cadherin预测胃癌根治术后患者预后不良的效能。结果 病例组ProGRP、IGF-1表达水平均高于对照组,E-cadherin表达水平低于对照组,差异均有统计学意义(P<0.05)。术后7 d, 80例患者的血清ProGRP、IGF-1水平均低于入院时,E-cadherin水平高于入院时(P<0.05)。ROC曲线分析结果显示,ProGRP、IGF-1和E-cadherin三者联合预测胃癌根治术后患者预后不良的AUC为0.831(95%CI:0.756~0.906),敏感度为(90.32%),特异度为(87.76%),高于单一指标(P<0.05)。结论 血清ProGRP、IGF-1和E-cadherin与胃癌根治术预后均存在关联,三者联合检测有利于提高预测效能。Objective To investigate the expression of pro-gastrin-releasing peptide(ProGRP),insulin-like growth factor 1(IGF-1)and E-cadherin in gastric cancer and their relationship with prognosis.Methods Eighty patients with gastric cancer admitted to Affiliated Hospital of Shandong Second Medical University from January 2021 to January 2022 and 45 healthy individuals undergoing physical examinations were selected as the research subjects.The case group is further divided into a good prognosis group and a poor prognosis group respectively.The differences in the levels of va-rious indicators between the two groups were compared.The serum levels of ProGRP,IGF-1,and E-cadherin of the 80 patients at admission and 7 days after surgery were compared.Meanwhile,the general data of patients in the good progno-sis group and the poor prognosis group were collected,and the receiver operating characteristic(ROC)curve was drawn to evaluate the efficacy of ProGRP,IGF-1,and E-cadherin in predicting poor prognosis in patients after radical gastrecto-my for gastric cancer.Results Compared with the control group,the expression levels of ProGRP and IGF-1 in the case group were higher,while the expression level of E-cadherin was lower,with statistically significant differences(P<0.05).Seven days after surgery,the serum ProGRP and IGF-1 levels of the 80 patients were lower compared to their levels upon admission,and the level of E-cadherin was higher than that at admission(P<0.05).ROC curve analysis results showed that the AUC,sensitivity and specificity of ProGRP,IGF-1 and E-cadherin in predicting poor prognosis after radical gas-troctomy were 0.831(95%CI:0.756~0.906),90.32%and 87.76%respectively which was higher than single index(P<0.05).Conclusion Serum ProGRP,IGF-1 and E-cadherin are associated with the prognosis of gastric cancer after radical operation.The combined detection of the three is conducive to improving the prediction efficiency.

关 键 词：胃肿瘤 胃泌素释放肽前体 胰岛素样生长因子-1 上皮细胞钙黏素 

分 类 号：R735.2[医药卫生—肿瘤]