丙酮酸激酶M2在神经系统疾病中的研究进展  

Research progress in roles of pyruvate kinase M2 in neurological diseases

作　　者：谭继元 高妍 李京超 殷悦 罗文哲[1] 王妍 TAN Jiyuan;GAO Yan;LI Jingchao;YIN Yue;LUO Wenzhe;WANG Yan(School of Basic Medical Sciences,Jiamusi University,Jiamusi,Heilongjiang 154000,China;Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100850,China)

机构地区：[1]佳木斯大学基础医学院,黑龙江佳木斯154000 [2]军事科学院军事医学研究院,北京100850

出　　处：《军事医学》2025年第2期152-157,共6页Military Medical Sciences

基　　金：黑龙江省省属高等学校基本科研业务费科研项目(2021-KYYWF-0597);东极学术建设团队项目(DJXSTD202404)。

摘　　要：丙酮酸激酶M2(PKM2)与多种神经系统疾病有着密切联系,其通过有氧糖酵解、氧化应激、炎症反应、细胞凋亡等多种机制参与阿尔茨海默病、帕金森病、多发性硬化症、创伤性脑损伤等神经系统疾病的发生发展。该文通过概述PKM2的生物学特性及其在神经系统疾病的病理生理机制中的作用,可以更好地了解PKM2与神经系统疾病的发生发展的联系,以期为神经系统疾病的治疗提供新的思路。Pyruvate kinase M2(PKM2)is closely linked to a variety of neurological disorders,involved in the onset and progression of a wide range of diseases,including Alzheimer′s disease,Parkinson′s disease,multiple sclerosis and traumatic brain injury through such mechanisms as aerobic glycolysis,oxidative stress,inflammation and apoptosis.This review is intended to provide an overview of the biological characteristics of PKM2 and its role in the pathophysiological mechanisms of neurological disorders.A better understanding of the correlations between PKM2 and the development of neurological diseases can offer new insights into and references for the clinical diagnosis and treatment of these conditions.

关 键 词：丙酮酸激酶M2 神经系统疾病 糖酵解 氧化损伤 

分 类 号：R363[医药卫生—病理学] R741.02[医药卫生—基础医学]