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作 者:坎毛措 万代草 周太才让 德吉卓玛 白玛措 热增才旦 文成当智 Kanmaocuo;Wandaicao;Zhoutaicairang;Dejizhuoma;Baimacuo;Rezengcaidan;Wenchengdangzhi(College of Pharmacy,Qinghai Minzu University,Xining 810007,China)
出 处:《中国现代中药》2025年第4期661-666,共6页Modern Chinese Medicine
基 金:国家自然科学基金项目(82460845);青海省科技计划项目(2022-ZJ-958Q);高层次人才(博士)“领雁”项目(23GCC15)。
摘 要:目的:测定烈香杜鹃发酵物的挥发油成分及其抑菌活性,为充分利用烈香杜鹃发酵物资源提供理论依据。方法:遵循藏族药古籍文献《藏药炮制实践精选》记载的炮制方法对烈香杜鹃进行发酵;通过超临界CO_(2)法提取挥发油;利用气相色谱-质谱法(GC-MS)分离其挥发油成分,并采用滤纸片法研究其抑菌活性。结果:从烈香杜鹃发酵物挥发油中共鉴定出63个化学成分,其中主要含异炔诺酮(2.95%)、三甲基硅烷基棕榈酸酯(2.82%)、5-乙基-2-甲基辛烷(2.08%)、2,6,11-三甲基十二烷(1.84%)、3,7-二甲基癸烷(1.69%)等成分。抑菌实验结果显示其发酵物对大肠埃希菌、藤黄微球菌、金黄色葡萄球菌、痢疾志贺菌、乙型副伤寒沙门菌、短小芽孢杆菌等具有不同的抑菌活性。结论:烈香杜鹃中含有丰富的挥发油成分,因此结合其发酵物挥发油成分分析和抑菌实验,阐明了其治疗皮肤病、细菌性感染的关节炎等疾病的疗效基础,同时为其发酵物的开发应用提供参考。Objective:This study aimed to identify the volatile oil components of the Rhododendron anthopogonoides Maxim.(RAM)fermented product and evaluate their antibacterial activity,providing a theoretical basis for the comprehensive utilization of the RAM fermented product resources.Methods:RAM was fermented according to the processing method recorded in an ancient Tibetan book,Selected Practices of Tibetan Medicine Preparation.Volatile oils were extracted using the supercritical carbon dioxide(CO_(2))method,and its components were separated using the gas chromatography-mass spectrometry(GC-MS)method.The antibacterial activity was assessed using the filter paper method.Results:A total of 63 chemical components were identified from the volatile oils of the RAM fermented product,mainly containing norethynodrel(2.95%),trimethylsilyl palmitate(2.82%),5-ethyl-2-methyl-octane(2.08%),2,6,11-trimethyldodecane(1.84%),3,7-dimethyldecane(1.69%),and other components.The RAM fermented product shows varying antibacterial activities against Escherichia coli,Micrococcus luteus,Staphylococcus aureus,Shigella dysenteriae,Salmonella paratyphi B,Bacillus pumilus,etc.Conclusion:RAM is rich in volatile oil components.Based on the analysis of volatile oil components of its fermented product and antibacterial tests,the basis of its effect in treating skin diseases,septic arthritis,and other diseases is clarified,providing support for the development and application of RAM fermented product.
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