浸润性乳腺癌组织中P63、CK5/6表达与临床病理特征的关系  

Correlations of the expressions of P63 and CK5/6 with clinicopathological characteristics of invasive breast cancer

作　　者：张娜娜 Zhang Nana(Department of Pathology,Zhumadian Central Hospital,Zhumadian 463000,China)

机构地区：[1]驻马店市中心医院病理科,驻马店463000

出　　处：《中国实用医刊》2025年第4期27-31,共5页Chinese Journal of Practical Medicine

摘　　要：目的分析浸润性乳腺癌(IBC)组织中P63、CK5/6表达与临床病理特征的关系。方法前瞻性抽取2022年2月至2023年2月于驻马店市中心医院接受乳腺癌根治术治疗的146例IBC患者,术中获取肿瘤组织标本,采用免疫组织化学法检测组织中P63、CK5/6表达情况,收集并记录患者的临床病理特征和随访1年预后情况,分析组织中P63、CK5/6表达与IBC临床病理特征和预后的关系。结果P63、CK5/6在乳腺癌组织中阳性表达率高于癌旁组织(P<0.05)。P63阳性表达者TNM分期为Ⅲ期、淋巴结转移、HER-2阳性表达占比高于P63阴性表达者(P<0.05);CK5/6阳性表达者TNM分期为Ⅲ期、组织学分级为3级、淋巴结转移和Ki-67增殖指数≥20%占比高于CK5/6阴性表达者(P<0.05)。经χ^(2)检验的Cramer’sν系数分析结果显示,P63表达与IBC患者TNM分期、淋巴结转移、HER-2有关,CK5/6表达与IBC患者TNM分期、组织学分级、淋巴结转移、Ki-67有关(P<0.05)。随访1年,P63阳性表达者和P63阴性表达者患者总生存率分别78.57%(22/28)、96.61%(114/118);CK5/6阳性表达者和CK5/6阴性表达者总生存率分别为76.19%(16/21)、96.00%(120/125)。经Log-rankχ^(2)检验结果显示,P63和CK5/6阳性表达者总生存期短于P63和CK5/6阴性表达者(P<0.05)。相关性分析结果显示,组织中P63、CK5/6表达与IBC患者的总体生存期存在显著关联(P<0.05)。结论IBC组织中P63、CK5/6阳性表达率较高,且组织中P63、CK5/6表达与IBC临床病理特征和预后均有关。ObjectiveTo analyze the correlations of the expression of tumor protein 63(P63)and cytokeratin 5/6(CK5/60)with the clinicopathological characteristics of invasive breast cancer(IBC).MethodsA total of 146 patients with IBC who received radical surgery in Zhumadian Central Hospital from February 2022 to February 2023 were prospectively selected.Th tumor tissue was extracted during the surgery,and then,the expressions of P63 and CK5/6 in tissues were detected by immunohistochemistry.The clinicopathological features and prognosis during 1-year follow up of patients were collected and recorded.The correlations of the expressions of P63 and CK5/6 in tissues with the clinicopathological features and prognosis of IBC were analyzed.ResultsThe positive expression rates of P63 and CK5/6 in breast cancer tissue were higher than those in adjacent tissue(P<0.05).The proportion of tumor,node and metastasis(TNM)stage III,lymph node metastasis,and the proportion of human epidermal growth factor receptor 2(HER-2)positive expression in the P63 positive expression patients were higher than those in the P63 negative expression patients(P<0.05).The proportion of TNM stage III,histological grade 3,lymph node metastasis,and Ki-67 proliferation index more than 20%in the CK5/6 positive expression patients were higher than those in the CK5/6 negative expression patients(P<0.05).Cramer’sνcoefficient analysis byχ^(2)test showed that P63 expression was associated with TNM stage,lymph node metastasis,and HER-2 in IBC patients;while CK5/6 expression was associated with TNM stage,histological grade,lymph node metastasis,and Ki-67 in IBC patients(P<0.05).After one year of follow-up,the overall survival rates of patients with P63 positive expression and patients with P63 negative expression were 78.57%(22/28)and 96.61%(114/118),respectively.The overall survival rates of the CK5/6 positive expression patients and the CK5/6 negative expression patients were 76.19%(16/21)and 96.00%(120/125),respectively.The Log-rankχ^(2)test results showed that

关 键 词：乳腺癌 P63 CK5/6 病理特征 预后 

分 类 号：R737.9[医药卫生—肿瘤]