妊娠合并血友病A患者足月分娩一例  

A Case of Full-Term Delivery in A Pregnant Patient with Hemophilia A

作　　者：陈晓娟 张艳馨[1] CHEN Xiao-juan;ZHANG Yan-xin(Northern Jiangsu People′s Hospital,Yangzhou 225001,Jiangsu Province,China)

机构地区：[1]苏北人民医院,江苏省扬州市225001

出　　处：《国际妇产科学杂志》2025年第2期158-160,共3页Journal of International Obstetrics and Gynecology

摘　　要：报告1例妊娠合并血友病A患者足月剖宫产终止妊娠的病例。该患者为凝血因子Ⅷ(coagulation factorⅧ,FⅧ)基因异常引起的血友病A型,平素表现为磕碰外伤等出血时间较长和间断出现牙龈出血,其母亲和姐姐为血友病基因携带者,患者既往有过一次胎儿血友病引产史。妊娠期患者在产科门诊及血液科门诊严密监测,定期复查FⅧ活性(FⅧ:C)、血浆FⅧ抑制物及凝血功能。足月前3天入院,完善相关检查并予凝血因子输注治疗,于孕37周因臀位足月剖宫产终止妊娠,手术顺利,术中出血300 mL,新生儿体质量2 990 g,出生后1 min、5 min Apgar评分均为10分,送至新生儿科进一步观察,患者术后无异常出血,产后11 d顺利出院,其新生儿5 d出院,母儿结局良好。A case of termination by caesarean section in a pregnant patient with hemophilia A was reported.In this study,the patient had hemophilia A caused by an abnormal coagulation factorⅧ(FⅧ)gene,and usually characterized by long bleeding time and intermittent bleeding such as bump trauma.Her mother and elder sister are both carriers of the hemophilia gene,and she had once induced labor with fetal hemophilia.During pregnancy,the patient was closely monitored in the obstetric and hematology clinics,and the activity of FⅧ(FⅧ:C),plasma FⅧinhibitor and coagulation function were regularly rechecked.The patient was hospitalized three days before term,completed those examination and treated with coagulation factor transfusion.The patient was successfully terminated by full-term cesarean section at 37 weeks of gestation,and the indication for surgery is breech presentation.The surgery went smoothly,the intraoperative bleeding was 300 mL as normal.The newborn weighed 2990 g,the Apgar score of 1 min and 5 min after birth was 10 points,and was sent to the neonatal department for further observation.The patient had no abnormal bleeding after surgery,and was successfully discharged on the 11th day postpartum,the newborn was discharged on the 5th day,the maternal and child have a good outcome.

关 键 词：妊娠 血友病A 足月分娩 治疗 病例报告 

分 类 号：R714.2[医药卫生—妇产科学]