吲哚菁绿示踪前哨淋巴结在早期宫颈癌中的应用  

Clinical Application of Indocyanine Green Tracing of Sentinel Lymph Nodes in Early Cervical Cancer

作　　者：柴玲娜 李艳丽 石洁(审校) 高晗 欧阳夕颜 程诗语 CHAI Ling-na;LI Yan-li;SHI Jie;GAO Han;OUYANG Xi-yan;CHENG Shi-yu(Wuhan University of Science and Technology,School of Medicine,Wuhan 430065,China;Department of GynecologyⅡ,Maternal and Child Health Hospital of Hubei Province,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430070,China)

机构地区：[1]武汉科技大学医学院,430065 [2]华中科技大学同济医学院附属湖北省妇幼保健院妇科Ⅱ

出　　处：《国际妇产科学杂志》2025年第2期175-179,共5页Journal of International Obstetrics and Gynecology

基　　金：2020年武汉市中青年医学骨干人才(705020207)。

摘　　要：宫颈癌是威胁女性健康的恶性肿瘤之一,其传统手术清扫范围通常为系统性淋巴结清扫,但该方法可能导致术后并发症增多,影响患者生活质量。前哨淋巴结活检(sentinel lymph node biopsy,SLNB)技术旨在评估患者的淋巴结转移状态,为部分前哨淋巴结(sentinel lymph node,SLN)阴性患者减少了不必要的淋巴结清扫,从而降低手术创伤。吲哚菁绿(indocyanine green,ICG)作为一种荧光示踪剂,在早期宫颈癌的SLNB中显示出高敏感度和特异度,检出率优于生物染料、纳米碳悬液和放射性核素,是目前最常用的示踪剂之一。因其组织穿透力有限,进一步研究应关注ICG联合载体技术的临床转化,以克服现有技术的局限性。综述ICG示踪SLN在早期宫颈癌中的应用,为推进SLNB技术的临床应用提供参考。Cervical cancer is one of the malignant tumors that threaten women′s health.The traditional surgical approach typically involves systemic lymph node dissection,which may lead to increased postoperative complications and affect the quality of life of patients.Sentinel lymph node biopsy(SLNB)technology aims to assess the lymph node metastasis status of patients and reduce unnecessary lymph node dissection for some patients with negative sentinel lymph node(SLN),thereby reducing surgical trauma.Indocyanine green(ICG),as a fluorescent tracer,has shown high sensitivity and specificity in SLNB for early cervical cancer,with a detection rate superior to that of biological dyes,carbon nanoparticles,and radioactive isotopes.It is currently one of the most commonly used tracers.Due to its limited tissue penetration,further research should focus on the clinical transformation of ICG combined with carrier technology to overcome the limitations of existing techniques.This article aims to provide a comprehensive review of the application of ICG-traced SLN in early cervical cancer,providing a reference to promote the clinical application of SLNB technology.

关 键 词：前哨淋巴结 前哨淋巴结活组织检查 吲哚花青绿 宫颈肿瘤 示踪剂 

分 类 号：R737.33[医药卫生—肿瘤]