老年精神分裂症住院患者自杀倾向的影响因素分析  

Analysis of influencing factors of suicide tendency in elderly inpatients with schizophrenia

作　　者：刘峰 桂琴 LIU Feng;GUI Qin(Department of Clinical Laboratory,the Fifth People's Hospital of Jiujiang,Jiangxi Province,Jiujiang332000,China)

机构地区：[1]江西省九江市第五人民医院检验科,江西九江332000

出　　处：《中国当代医药》2025年第10期50-54,共5页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(202211754)。

摘　　要：目的探讨老年精神分裂症住院患者发生自杀倾向的关系,以期减少自杀率。方法选取2018年7月至2023年12月九江市第五人民医院检验科收治的80例老年精神分裂症住院患者作为研究对象,采用贝克自杀意念问卷中文版(BSI-CV)判断患者有无自杀倾向,并将其分为有自杀倾向组(n=21)和无自杀倾向组(n=59),收集两组人口学资料,并抽取受试者空腹静脉血经全自动生化分析仪测定其血清促甲状腺激素(TSH)、催乳素(PRL)、C反应蛋白(CRP)水平,使用Spearman相关分析法分析血清TSH、PRL、CRP水平与老年精神分裂症住院患者自杀倾向的相关性,采用logistic回归模型分析老年精神分裂症住院患者发生自杀倾向相关危险因素。结果有自杀倾向组血清TSH低于无自杀倾向组,PRL、CRP均高于无自杀倾向组,差异有统计学意义(P<0.05);Spearman相关分析显示血清TSH与BSI-CV评分呈负相关(P<0.05),但PRL、CRP与BSI-CV评分呈正相关(P<0.05);比较差异有统计学意义(P<0.05);单因素分析结果显示,性别、年龄、是否有过自杀未遂等与发生自杀倾向有关,差异有统计学意义(P<0.05);多因素分析采用logistic回归模型进行多因素分析结果显示,女性(β=0.166,OR=2.145,95%CI:0.018~2.307)、年龄大(β=1.024,OR=2.027,95%CI:1.470~2.896)、有过自杀未遂(β=1.005,OR=2.548,95%CI:0.490~5.063)、PRL(β=1.156,OR=2.119,95%CI:0.630~2.914)、CRP(β=0.541,OR=2.185,95%CI:0.598~6.024)为老年精神分裂症住院患者出现自杀倾向的危险因素,TSH(β=-1.234,OR=0.098,95%CI:0.874~4.021)为保护因素(P<0.05)。结论老年精神分裂症住院患者出现自杀倾向的情况较为严重,临床可通过血清TSH、PRL、CRP水平及性别、年龄、是否有过自杀未遂等相关危险因素的监测,及时发现异常并实施针对性干预对策,以减少自杀发生改善患者预后结局。Objective To explore the relationship between suicide tendency in elderly hospitalized patients with schizophrenia,in order to reduce the suicide rate.Methods A total of 80 elderly patients with schizophrenia admitted to the Department of Clinical Laboratory of the Fifth People's Hospital of Jiujiang from July 2018 to December 2023 were selected as the study objects.The Beck scale for suicidal ideation-Chinese version(BSI-CV)was used to determine whether the patients had suicidal intention,and they were divided into suicidal intention group(n=21)and non-suicidal intention group(n=59).Demographic data of the two groups were collected,and fasting venous blood of the subjects were collected and the levels of serum thyrotropin(TSH),prolactin(PRL)and C-reactive protein(CRP)were determined by automatic biochemical analyzer.Spearman correlation analysis was used to analyze the correlation between serum TSH,PRL and CRP levels and suicide tendency in elderly inpatients with schizophrenia,and logistic regression model was used to analyze the risk factors related to suicide tendency in elderly inpatients with schizophrenia.Results Serum TSH in the suicidal group was lower than that in the non-suicidal group,PRL and CRP were higher than those in the non-suicidal group,the differences were statistically significant(P<0.05).Spearman correlation analysis showed that serum TSH was negatively correlated with BSI-CV score,but PRL and CRP were positively correlated with BSI-CV score,the differences were statistically significant(P<0.05).The results of univariate analysis showed that gender,age,suicide attempt and so on were related to the occurrence of suicide intention,and the differences were statistically significant(P<0.05).Multivariate analysis using logistic regression model showed that female(β=0.166,OR=2.145,95%CI:0.018-2.307),elder(β=1.024,OR=2.027,95%CI:1.470-2.896),had attempted suicide(β=1.005,OR=2.548,95%CI:0.490-5.063),PRL(β=1.156,OR=2.119,95%CI:0.630-2.914),CRP(β=0.541,OR=2.185,95%CI:0.598-6.024)were the risk fa

关 键 词：血清促甲状腺素 催乳素 C反应蛋白 老年精神分裂症 住院 自杀倾向 

分 类 号：R749[医药卫生—神经病学与精神病学]