前列腺癌中CECR2表达与M2型巨噬细胞分布的相关性研究  

Correlation of CECR2 expression in prostate cancer with the distribution of M2 macrophages

作　　者：吕宸 彭丽娟[2] 何俊睿 刘旭 龙琼先[2] 伍季[1] LV Chen;PENG Li-juan;HE Jun-rui;LIU Xu;LONG Qiong-xian;WU Ji(Department of Urology,Nanchong Central Hospital,Second Clinical College of North Sichuan Medical College,Nanchong 637000,Sichuan,China;Department of Pathology,Nanchong Central Hospital,Second Clinical College of North Sichuan Medical College,Nanchong 637000,Sichuan,China;不详)

机构地区：[1]川北医学院第二临床医学院·南充市中心医院泌尿外科,四川南充637000 [2]川北医学院第二临床医学院·南充市中心医院病理科,四川南充637000 [3]不详

出　　处：《川北医学院学报》2025年第4期416-420,共5页Journal of North Sichuan Medical College

基　　金：四川省南充市科技局项目(KY-22JCYJPT0033)。

摘　　要：目的:分析前列腺癌组织中CECR2的表达及M2型巨噬细胞的分布情况,探讨前列腺癌进展中CECR2表达与M2型巨噬细胞分布的关系。方法:收集接受前列腺癌手术的98例住院患者临床及组织标本数据。应用免疫组织化学染色检测前列腺癌组织中猫眼综合征染色体候选基因2(CECR2)和CD163抗体的表达情况,分析其表达与临床病理特征的关系。结果:CECR2在良性前列腺组织中高表达,阳性率为87.76%;在前列腺癌组织中低表达,其阳性率为28.57%。前列腺癌组织中CECR2的阳性率低于癌旁良性前列腺组织(P<0.05)。前列腺癌组织中CECR2低表达与有无神经侵犯、前列腺外扩散、导管内癌及肿瘤分级分组、T分期密切相关(P<0.05)。在前列腺癌组织中,每高倍视野下CD163+M2型巨噬细胞的中位数为21.03个;癌旁良性前列腺组织的中位数为4.23个。前列腺癌组织中的CD163阳性巨噬细胞浸润密度高于其周边的良性前列腺组织(P<0.05)。进一步分析前列腺癌组织中CECR2表达与M2型巨噬细胞分布的关系显示,CECR2低表达的70例前列腺癌中有47例存在M2型巨噬细胞(CD163阳性)高密度分布,CECR2的低表达与M2型巨噬细胞高密度分布正相关(P<0.05)。结论:前列腺癌组织中存在CECR2表达水平下调,且其低表达与M2型巨噬细胞的浸润密度有关,CECR2可能通过诱导M2巨噬细胞极化,调控肿瘤免疫微环境,进而促进前列腺癌的进展。Objective:To analyze the expression of CECR2 and the distribution of M2 macrophages in prostate cancer tissues,and to explore the relationship between the expression of CECR2 and the distribution of M2 macrophages in the progression of prostate cancer.Methods:Clinical and tissue specimen data of 98 inpatients who underwent prostate cancer surgery were collected.The expressions of cat-eye syndrome chromosome region candidate gene 2(CECR2)and CD163 antibody in prostate cancer tissues were detected by immunohistochemical staining,and the relationship between their expressions and clinicopathological features was analyzed.Results:CECR2 was highly expressed in benign prostate tissues,with a positive rate of 87.76%,while it was lowly expressed in prostate cancer tissues,with a positive rate of 28.57%.The positive rate of CECR2 in prostate cancer tissues was lower than that in adjacent benign prostate tissues(P<0.05).The low expression of CECR2 in prostate cancer tissues was closely related to the presence of nerve invasion,extraprostatic spread,intraductal carcinoma,tumor grade and T stage(P<0.05).The median number of CD163-positive macrophages(M2 macrophages)in prostate cancer tissues was 21.03 per high-power field,while that in adjacent benign prostate tissues was 4.23 per high-power field.The infiltration density of CD163-positive macrophages in cancer tissues was higher than that in adjacent benign prostate tissues.Further analysis of the relationship between the expression of CECR2 and the distribution of M2 macrophages showed that 47 of the 70 cases with low expression of CECR2 had high-density distribution of M2 macrophages(CD163 positive),and the low expression of CECR2 was positively correlated with high-density distribution of M2 macrophages.Conclusion:There is a significant downregulation of CECR2 expression in prostate cancer tissues,and its low expression is related to the infiltration density of M2 macrophages.CECR2 may induce M2 macrophage polarization,regulate the tumor immune microenvironment,and there

关 键 词：前列腺癌 猫眼综合征染色体候选基因2 肿瘤微环境 肿瘤相关巨噬细胞 CD163 

分 类 号：R737.1[医药卫生—肿瘤]