盐酸米诺环素联合头孢呋辛酯片治疗对牙周病变患者牙周功能的影响  

Effect of combined treatment of minocycline hydrochloride and cefuroxime axetil tablets on periodontal function in patients with periodontal lesions

作　　者：童丽 厚岳森 许蕾 TONG Li;HOU Yue-sen;XU Lei(Department of Stomatology,Zhangjiagang First People's Hospital,Zhangjiagang 215600,Jiangsu,China)

机构地区：[1]张家港市第一人民医院口腔科,江苏张家港215600

出　　处：《川北医学院学报》2025年第4期442-445,共4页Journal of North Sichuan Medical College

基　　金：江苏省科技项目(BE2022770)。

摘　　要：目的:探究盐酸米诺环素联合头孢呋辛酯片治疗对牙周病变患者牙周功能的影响。方法:将120例牙周病变患者按照干预方式不同分为对照组(基础牙周治疗+头孢呋辛酯片治疗,n=60)和观察组(对照组基础上+盐酸米诺环素治疗,n=60),两组均治疗4周。比较两组患者治疗疗效、牙周临床指数、疼痛(VAS)评分、龈沟液炎症因子[白细胞介素-1β(IL-1β)、前列腺素E2(PGE2)和白细胞介素-8(IL-8)]水平及不良反应发生情况。结果:观察组治疗总有效率高于对照组(P<0.05);治疗4周后,两组龈沟出血指数、探诊深度和菌斑指数、VAS评分、IL-1β、PGE2和IL-8均较治疗前降低(P<0.05),且观察组均低于对照组(P<0.05);两组不良反应总发生率无统计学差异(P>0.05)。结论:盐酸米诺环素联合头孢呋辛酯片治疗牙周病变患者疗效确切,能有效改善患者牙周功能,缓解疼痛,降低炎症反应,值得推广。Objective:To investigate the effect of combined treatment of minocycline hydrochloride and cefuroxime axetil tablets on periodontal function in patients with periodontal lesions.Methods:120 patients with pulp and periodontal lesions were divided into a control group(n=60,basic periodontal treatment+cefuroxime axetil treatment)and an observation group(n=60,control group+minocycline hydrochloride)according to different intervention methods,both treated for 4 weeks.The therapeutic efficacy,periodontal clinical indices,pain(VAS)score,gingival crevicular fluid inflammatory factors[interleukin-1β,prostaglandin E2(PGE2),and interleukin-8(IL-8)],and the incidence of adverse reactions were compared between the two groups.Results:The overall response rate in the observation group was higher than that in the control group(P<0.05).After 4 weeks of treatment,both groups exhibited a reduction in gingival bleeding index,probing depth,plaque index,VAS scores,IL-1β,PGE2,and IL-8(P<0.05),and the observation group was lower than the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combined treatment of minocycline hydrochloride and cefuroxime axetil tablets in patients with periodontal lesions is effective,can effectively improve periodontal function,relieve pain,and reduce inflammatory reactions,and is worth promoting.

关 键 词：盐酸米诺环素 头孢呋辛酯片 牙周病 炎症因子 

分 类 号：R781.4[医药卫生—口腔医学]