病灶直径3 cm以内肺癌患者纵隔淋巴结转移情况及其风险因素分析  

Analysis of mediastinal lymph node metastasis and its risk factors in lung cancer patients with lesions less than 3 cm in diameter

作　　者：刘毅 刘莉琼 胡亦蓉 周雄 卢秋良 LIU Yi;LIU Liqiong;HU Yirong;ZHOU Xiong;LU Qiuliang(Department of Thoracic and Cardiovascular Surgery,Yichun People's Hospital,Jiangxi Province,Yichun 336000,China;Department of Respiratory Internal Medicine,Yichun People's Hospital,Jiangxi Province,Yichun 336000,China;Department of Neurology,Yichun People's Hospital,Jiangxi Province,Yichun336000,China)

机构地区：[1]江西省宜春市人民医院胸心外科,江西宜春336000 [2]江西省宜春市人民医院呼吸内科,江西宜春336000 [3]江西省宜春市人民医院神经内科,江西宜春336000

出　　处：《中国当代医药》2025年第11期16-19,26,共5页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(202140870)。

摘　　要：目的探究病灶直径3 cm以内肺癌患者纵隔淋巴结转移情况及其危险因素。方法选取2022年1月至2024年1月宜春市人民医院收治的60例病灶直径3 cm以内肺癌患者作为研究对象,依据纵隔淋巴结转移情况分为转移组(n=25例)与未转移组(n=35),分析其危险因素。结果病灶直径3 cm以内肺癌患者中,病理类型为腺癌41例,非腺癌(鳞癌、腺鳞癌、大细胞癌)19例。两组年龄、肿瘤直径、肿瘤分化程度、肿瘤标志物、肺膜侵犯、气道播散、血管侵犯、磨玻璃结节比较,差异有统计学意义(P<0.05)。多因素logistic分析显示,年龄、肿瘤直径、肿瘤分化程度、肿瘤标志物、肺膜侵犯、气道播散、血管侵犯是肺癌患者纵隔淋巴结转移的独立危险因素,磨玻璃结节是肺癌患者纵隔淋巴结转移的独立保护因素(P<0.05)。结论年龄、肿瘤直径、肿瘤分化程度、肿瘤标志物、肺膜侵犯、气道播散、血管侵犯磨玻璃结节是肺癌患者纵隔淋巴结转移的影响因素,针对具有危险因素的病灶直径3 cm以内肺癌患者需重点关注,并采取有效的干预措施。Objective To investigate the mediastinal lymph node metastasis and its risk factors in lung cancer patients with lesions less than 3 cm in diameter.Methods A total of 60 patients with lung cancer within 3 cm in diameter admitted to Yichun People's Hospital from January 2022 to January 2024 were selected as the research objects.According to the mediastinal lymph node metastasis,they were divided into the metastasis group(n=25)and the non-metastasis group(n=35),and the risk factors were analyzed.Results Among the lung cancer patients with lesions less than 3 cm in diameter,41 cases were adenocarcinoma and 19 cases were non-adenocarcinoma(squamous cell carcinoma,adeno-squamous cell carcinoma,large cell carcinoma).There were significant differences in age,tumor diameter,tumor differentiation degree,tumor markers,pulmonary membrane invasion,airway spread,vascular invasion and ground glass nodules between the two groups(P<0.05).Multivariate logistic analysis showed that age,tumor diameter,tumor differentiation degree,tumor markers,pulmonary membrane invasion,airway spread,and vascular invasion were independent risk factors for mediastinal lymph node metastasis in lung cancer patients,and ground glass nodules was independent protective factor for mediastinal lymph node metastasis in lung cancer patients(P<0.05).Conclusion Age,tumor diameter,tumor differentiation degree,tumor markers pulmonary membrane invasion,airway spread,and vascular invasion ground glass nodules are the influencing factors for mediastinal lymph node metastasis in lung cancer patients.Attention should be paid to lung cancer patients with risk factors less than 3 cm in diameter,and effective intervention measures should be taken.

关 键 词：肺癌 病灶直径 纵隔淋巴结转移 影响因素 

分 类 号：R734.2[医药卫生—肿瘤]