首发精神分裂症男性患者代谢情况与心理社会功能的相关性分析  

Correlation analysis of metabolic conditions and psychosocial function in male patients with first-episode schizophrenia

作　　者：刘云斐 王小敏[2] LIU Yunfei;WANG Xiaomin(Department of Psychiatry,Nanhui Mental Health Center,Pudong New Area,Shanghai 201399,China;Department of Mental Health,the First Hospital of Hebei Medical University,Hebei Province,Shijiazhuang 050000,China)

机构地区：[1]上海市浦东新区南汇精神卫生中心精神科,上海201399 [2]河北医科大学第一医院精神卫生科,河北石家庄050000

出　　处：《中国当代医药》2025年第11期47-50,共4页China Modern Medicine

基　　金：上海市浦东新区南汇精神卫生中心科技项目(pdnj2022-01)。

摘　　要：目的分析首发精神分裂症(FES)男性患者的代谢与其心理社会功能的相关性。方法选取2023年1月至2024年1月就诊于上海市浦东新区南汇精神卫生中心就诊的53例符合《国际疾病分类-10》(ICD-10)诊断的FES男性患者作为研究对象。对患者进行人口统计学调查,阴性和阳性症状量表(PANSS)评估患者的精神病性症状的严重程度。评估患者代谢情况包括体重指数(BMI)、收缩压(SBP)、舒张压(DBP)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、空腹血糖(FPG)、血钾、载脂蛋白A1(ApoA-Ⅰ)、载脂蛋白B(ApoB)。根据功能大体评定量表(GAF)评分,定义GAF≥6为轻度功能损伤组(n=27),GAF<6为中重度功能损伤组(n=26)。结果两组患者的PANSS评分、TC、LDL-C、ApoB的比较,差异有统计学意义(P<0.05)。ApoB(rs=-0.341,95%CI:-0.566~-0.054,P=0.013)、LDL-C(rs=-0.279,95%CI:-0.571~-0.001,P=0.043)、PANSS评分(rs=-0.289,95%CI:-0.539~-0.025,P=0.036)与FES男性患者的心理社会功能呈负相关。结论本研究发现较高的ApoB、较高的LDL-C和较严重的精神病性症状的FES男性患者,其心理社会功能较差。Objective To analyze the correlation between metabolism and psychosocial function in male patients with first-episode schizophrenia(FES).Methods A total of 53 male patients diagnosed with FES according to the International Classification of Diseases-10(ICD-10)who visited the Nanhui Mental Health Center in Pudong New Area,Shanghai from January 2023 to January 2024 were selected as the research objects.Demographic surveys were conducted on the patients,and the severity of their psychotic symptoms was assessed using the positive and negative syndrome scale(PANSS).Metabolic assessments were evaluated,including body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),triglycerides(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),fasting plasma glucose(FPG),serum potassium,apolipoprotein A1(ApoA-I),and apolipoprotein B(ApoB).Based on the global assessment of functioning(GAF)scores,patients were defined as having mild functional impairment group if GAF≥6(n=27)and moderate to severe functional impairment group if GAF<6(n=26).Results There were significant differences in PANSS score,TC,LDL-C and ApoB between the two groups(P<0.05).ApoB(rs=-0.341,95%CI:-0.566--0.054,P=0.013),LDL-C(rs=-0.279,95%CI:-0.571--0.001,P=0.043),and PANSS scores(rs=-0.289,95%CI:-0.539--0.025,P=0.036)showed negative correlation with psychosocial function in male patients with FES.Conclusion This study found that male patients with FES who have higher apolipoprotein B,higher low-density lipoprotein cholesterol,and more severe psychotic symptoms tend to exhibit poorer psychosocial functioning.

关 键 词：精神分裂症 代谢 血脂 社会功能 

分 类 号：R749[医药卫生—神经病学与精神病学]