缺血性脑卒中患者并发认知功能障碍的影响因素分析  

Analysis of factors affecting acute ischemic stroke complicating cognitive dysfunction patients

作　　者：刘琳[1] LIU Lin(Department of Neurology,Jinan Third People's Hospital,Shandong Province,Jinan 250132,China)

机构地区：[1]济南市第三人民医院神经内科,山东济南250132

出　　处：《中国当代医药》2025年第11期55-59,共5页China Modern Medicine

摘　　要：目的探究缺血性脑卒中(AIS)患者并发认知功能障碍的影响因素。方法回顾性分析2022年7月至2024年3月山东省济南市第三人民医院神经内科收治210例AIS患者的临床资料,根据患者是否并发认知功能障碍将其分为发生组(60例)和未发生组(150例)。比较两组临床资料和疾病相关特征,采用logistic回归分析有差异项目,得出影响并发认知功能障碍的因素。结果两组年龄、规律运动、病变部位、合并基础疾病比较,差异有统计学意义(P<0.05),logistic分析结果显示,年龄≥60岁(β=1.183,OR=3.263,95%CI:1.738~6.126)、无规律运动(β=0.887,OR=2.429,95%CI:1.305~4.519)、病变部位(β=1.876,OR=6.526,95%CI:3.198~13.319)、有合并基础疾病(β=2.363,OR=10.625,95%CI:4.965~22.735)是影响AIS合并认知功能障碍发生的独立危险因素;相关性分析结果显示,年龄(r=0.260,P<0.001)、规律运动(r=0.196,P=0.004)、病变部位(r=0.380,P<0.001)、合并基础疾病(r=0.465,P<0.001)均与AIS合并认知功能障碍呈正相关。结论AIS并发认知功能障碍与年龄、规律运动、病变部位、合并基础疾病因素有关,需引起临床重视,尽早制订措施进行干预。Objective To investigate the factors influencing cognitive dysfunction in patients with acute ischemic stroke(AIS).Methods A total of 210 AIS patients admitted to the Department of Neurology,Jinan Third People's Hospital from July 2022 to March 2024 were selected as the research objects by retrospective analysis,and they were divided into the occurring group(60 cases)and the non-occurring group(150 cases)according to whether they had concurrent cognitive dysfunction or not.The clinical data and disease-related characteristics of the two groups were compared,logistic regression was used to analyze the items with differences and derive the factors affecting concurrent cognitive dysfunction.Results There were statistically significant differences in age,regular exercise,lesion site and underlying diseases between the two groups(P<0.05).Logistic analysis showed that age≥60 years old(β=1.183,OR=3.263,95%CI:1.738-6.126),irregular exercise(β=0.887,OR=2.429,95%CI:1.305-4.519),lesion site(β=1.876,OR=6.526,95%CI:3.198-13.319),and having comorbid underlying disease(β=2.363,OR=10.625,95%CI:4.965-22.735)were the independant risk factors affecting the occurrence of AIS comorbid cognitive dysfunction factors,correlation analysis showed that age(r=0.260,P<0.001),regular exercise(r=0.196,P=0.004),lesion site(r=0.380,P<0.001),and comorbid underlying diseases(r=0.465,P<0.001)were positively correlated with AIS comorbid cognitive dysfunction.Conclusion AIS complicating cognitive dysfunction is related to age,regular exercise,lesion site,and comorbid underlying disease factors,which need to be emphasized clinically and measures should be formulated to intervene as early as possible.

关 键 词：缺血性脑卒中 认知功能障碍 高血糖 高血压 

分 类 号：R741[医药卫生—神经病学与精神病学]