核因子E2相关因子2信号通路在糖尿病视网膜病变中的研究进展  

Research progress of nuclear factor E2-related factor 2 signaling pathway in diabetic retinopathy

作　　者：王淳玉 崔俊 李晓晖 崔仁哲[1] WANG Chunyu;CUI Jun;LI Xiaohui;CUI Renzhe(Department of Ophthalmology,Yanbian University Hospital,Jilin Province,Yanji 133000,China)

机构地区：[1]延边大学附属医院眼科,吉林延吉133000

出　　处：《中国当代医药》2025年第11期183-187,共5页China Modern Medicine

摘　　要：糖尿病视网膜病变(DR)已经成为40岁以上患者中最为普遍的视网膜病变,其发病率与致盲率均高于其他类型的视网膜疾病。氧化应激反应是DR的主要发病机制之一。Kelch样环氧氯丙烷相关蛋白1(Keap1)与核因子E2相关因子2(Nrf2)构成的Nrf2信号通路具有强大的抗氧化能力,能够有效地抵御外界氧化以及化学物质的刺激,被认为是机体内重要的内源性抗氧化信号通路。本综述旨在探讨Nrf2信号通路如何通过抗氧化应激作用来干预DR的发展,重点探讨其抗氧化应激和抗炎机制,以及针对该通路的药物治疗进展。本文指出,通过激活Nrf2信号通路,可以有效减缓DR的进展,为患者提供新的治疗策略。Diabetic retinopathy(DR)has become the most common retinopathy in patients over 40 years old,with a higher incidence and blinding rate than other types of retinal diseases.Oxidative stress is one of the main pathogenesis of DR.Nuclear factor erythroid-2 related factor 2(Nrf2)signaling pathway,composed of Kelch-like epichlorohydrin related protein 1(Keap1)and Nrf2,has a strong antioxidant capacity,which can effectively resist external oxidation and chemical stimulation,and is considered to be an important endogenous antioxidant signaling pathway in the body.The purpose of this review is to explore how the Nrf2 signaling pathway interferes with the development of DR through antioxidant stress.The focus is on its antioxidative stress and anti-inflammatory mechanisms,as well as the progress of drug therapy targeting this pathway.This article points out that by activating the Nrf2 signaling pathway,the progression of DR can be effectively slowed down,providing new treatment strategies for patients.

关 键 词：核因子E2相关因子2信号通路 糖尿病视网膜病变 Kelch样环氧氯丙烷相关蛋白1 治疗 

分 类 号：R774.1[医药卫生—眼科]