基于JAK2/STAT3信号通路的纤维化疾病治疗策略与中药应用的研究进展  

Research progress of fibrotic disease treatment strategy and application of Chinese medicine based on JAK2/STAT3 signaling pathway

作　　者：刘馨缘 谭羽欣 耿梓馨 金鹏 李钰 肖宇[1] 邓凤春[1] 赵红晔 LIU Xinyuan;TAN Yuxin;GENG Zixin;JIN Peng;LI Yu;XIAO Yu;DENG Fengchun;ZHAO Hongye(School of Basic Medicine,Qiqihar Medical University,Heilongjiang Province,Qiqihar 161006,China)

机构地区：[1]齐齐哈尔医学院基础医学院,黑龙江齐齐哈尔161006

出　　处：《中国当代医药》2025年第11期193-198,共6页China Modern Medicine

基　　金：国家级大学生创新创业训练计划项目(202211230054);黑龙江省齐齐哈尔医学科学院项目(QMSI2021B-13)。

摘　　要：纤维化疾病是一种多器官受累的病理状态,其特征是组织结构破坏和功能障碍,严重时可导致器官衰竭,对人类健康构成重大威胁。传统治疗方法虽旨在缓解症状和改善功能,但存在疗效不足、副作用和成本问题。酪氨酸激酶2/信号转导与转录激活因子3(JAK2/STAT3)信号通路在纤维化的发生发展中被证实发挥关键作用,为治疗提供了新思路。本文总结了JAK2/STAT3信号通路在心、肺、肝、肾等不同器官和组织的纤维化疾病中作用机制的研究进展,重点探讨了该信号通路作为纤维化疾病治疗靶点的潜力以及中药对于治疗纤维化疾病的应用前景。但JAK2/STAT3信号通路的具体调控机制和中药的作用机制仍需深入研究。未来研究方向应扩大样本量和种类,推进更广泛的临床试验,以明确JAK2/STAT3信号通路的作用机制和中药的治疗效果,推动纤维化疾病的靶向治疗和精准医疗发展。Fibrotic disease is a pathological state of multi-organ involvement,which is characterized by the destruction of tissue structure and dysfunction,and can lead to organ failure in severe cases,posing a major threat to human health.Although the traditional treatment is aimed at relieving symptoms and improving function,there are insufficient efficacy,side effects and cost problems.Janus kinase 2/signal transduction and activator of transcription 3(JAK2/STAT3)signaling pathway has been shown to play a key role in the occurrence and development of fibrosis,providing new ideas for treatment.This paper summarizes the research progress of the mechanism of JAK2/STAT3 signaling pathway in fibrotic diseases of different organs and tissues such as heart,lung,liver and kidney,focusing on the potential of this signaling pathway as a therapeutic target for fibrotic diseases and the application prospect of traditional Chinese medicine in the treatment of fibrotic diseases.However,the specific regulatory mechanism of JAK2/STAT3 signaling pathway and the action mechanism of traditional Chinese medicine still need to be further studied.The future research direction should expand the sample size and types,and promote more extensive clinical trials to clarify the mechanism of action of JAK2/STAT3 signaling pathway and the therapeutic effect of traditional Chinese medicine,and promote the development of targeted therapy and precision medicine for fibrotic diseases.

关 键 词：JAK2/STAT3信号通路 器官纤维化 中药应用 疾病机制 治疗靶点 

分 类 号：R285.6[医药卫生—中药学]