生长抑素持续静脉滴注治疗重症急性胰腺炎患者的效果观察  

Effect observation of continuous intravenous infusion of somatostatin in patients with severe acute pancreatitis

作　　者：王吟珺 WANG Yin-jun(Zhongshan Hospital Affiliated to Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学附属中山医院,200032

出　　处：《中国实用医药》2025年第7期82-86,共5页China Practical Medicine

摘　　要：目的探析重症急性胰腺炎(SAP)患者持续静脉滴注生长抑素(SST)的治疗效果。方法60例SAP患者,以抽签法分为对照组(常规治疗,30例)和观察组(常规治疗+SST治疗,30例)。比较两组疗效、体征消失时间、实验室指标、不良反应发生情况、生活质量评分。结果观察组总有效率96.67%高于对照组的80.00%(χ^(2)=4.043,P<0.05)。对照组肠鸣音恢复正常时间、排气恢复正常时间、排便恢复正常时间、腹胀消失时间、腹痛消失时间分别为(5.01±0.95)d、(33.24±3.53)h、(55.22±9.21)h、(5.33±1.13)d、(5.32±0.68)d,观察组分别为(3.34±0.46)d、(21.24±1.32)h、(32.22±4.15)h、(3.22±0.45)d、(4.12±0.23)d,观察组均短于对照组(P<0.05)。治疗后,两组肿瘤坏死因子-α、白细胞介素-6、超敏C反应蛋白、内毒素、二胺氧化酶、血清淀粉酶均较治疗前降低,且观察组肿瘤坏死因子-α(1.32±0.22)ng/L、白细胞介素-6(61.34±2.12)pg/ml、超敏C反应蛋白(7.15±1.21)mg/L、内毒素(7.01±1.32)EU/ml、二胺氧化酶(11.98±1.06)U/L、血清淀粉酶(723.98±125.05)U/L均低于对照组的(2.24±0.22)ng/L、(121.12±2.12)pg/ml、(9.25±1.56)mg/L、(11.24±1.61)EU/ml、(18.34±1.45)U/L、(1133.93±215.22)U/L(P<0.05)。两组不良反应发生率比较无差异(χ^(2)=0.741,P>0.05)。治疗前,对照组生理功能、心理能力、社交能力、精神/信仰、环境状态评分分别为(71.47±3.23)、(73.47±3.29)、(75.42±3.27)、(79.69±3.51)、(76.41±3.57)分,与观察组的(71.63±3.32)、(72.57±3.31)、(75.56±3.89)、(79.48±3.21)、(76.53±4.28)分比较无差异(P>0.05);治疗后,观察组生理功能、心理能力、社交能力、精神/信仰、环境状态评分分别为(91.71±3.57)、(92.47±3.63)、(92.38±3.25)、(93.29±3.68)、(95.49±3.12)分,均高于对照组的(85.82±3.81)、(82.83±4.72)、(86.41±3.57)、(85.37±3.67)、(83.83±4.67)分(P<0.05)。结论SAP患者接受SST持续静脉滴注可获得显著效用,值得推广。Objective To explore the effect of continuous intravenous infusion of somatostatin(SST)in patients with severe acute pancreatitis(SAP).Methods 60 SAP patients were selected and divided into control group(conventional treatment,30 cases)and observation group(conventional treatment+SST,30 cases)by lottery method.The efficacy,disappearance time of signs,laboratory indexes,occurrence of adverse reactions and quality of life score were compared between the two groups.Results The total effective rate of 96.67%in the observation group was higher than 80.00%in the control group(χ^(2)=4.043,P<0.05).In the control group,the recovery time of bowel sound,exhaust,defecation,abdominal distension and abdominal pain were(5.01±0.95)d,(33.24±3.53)h,(55.22±9.21)h,(5.33±1.13)d and(5.32±0.68)d,and those in the observation group were(3.34±0.46)d,(21.24±1.32)h,(32.22±4.15)h,(3.22±0.45)d and(4.12±0.23)d;the observation group was shorter than the control group(P<0.05).After treatment,the tumor necrosis factor-α,interleukin-6,hypersensitive C-reactive protein,endotoxin,diamine oxidase and serum amylase were decreased in both groups compared with before treatment;the observation group had tumor necrosis factor-αof(1.32±0.22)ng/L,interleukin-6 of(61.34±2.12)pg/ml,hypersensitive C-reactive protein of(7.15±1.21)mg/L,endotoxin of(7.01±1.32)EU/ml,diamine oxidase of(11.98±1.06)U/L,and serum amylase of(723.98±125.05)U/L,which were lower than(2.24±0.22)ng/L,(121.12±2.12)pg/ml,(9.25±1.56)mg/L,(11.24±1.61)EU/ml,(18.34±1.45)U/L,and(1133.93±215.22)U/L in the control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(χ^(2)=0.741,P>0.05).Before treatment,the scores of physical functioning,mental ability,social ability,spirituality/belief,and environmental status in the control group were(71.47±3.23),(73.47±3.29),(75.42±3.27),(79.69±3.51),and(76.41±3.57)points,and those in the observation group were(71.63±3.32),(72.57±3.31),(75.56±3.89),(79.48±3.21),and(76.53±4.28)points;

关 键 词：生长抑素 重症急性胰腺炎 疗效 不良反应 

分 类 号：R576[医药卫生—消化系统]