双样本孟德尔随机化研究炎症蛋白因子与抑郁症的因果关联  

Two-sample Mendelian randomization study on the causal association between inflammatory protein factors and depression

作　　者：黄绍伟 杨薇 许秀峰[3] 廉坤[4] HUANG Shaowei;YANG Wei;XU Xiufeng;LIAN Kun(Department of Critical Care Medicine,Yunnan Provincial Hospital of Infectious Disease/Yunnan Mental Health Center,Kunming,Yunnan 650101,China;Department of Psychiatry,The Second People′s Hospital of Yuxi,Yuxi,Yunnan 653100,China;Department of Psychiatry,The First Affiliated Hospital of Kunming Medical University,Kunming,Yunnan 650032,China;Department of Neurosurgery,The Second Affiliated Hospital of Kunming Medical University,Kunming,Yunnan 650101,China)

机构地区：[1]云南省传染病医院/云南省心理卫生中心重症医学科,云南昆明650101 [2]玉溪市第二人民医院精神科,云南玉溪653100 [3]昆明医科大学第一附属医院精神科,云南昆明650032 [4]昆明医科大学第二附属医院神经外科,云南昆明650101

出　　处：《现代医药卫生》2025年第4期822-827,835,共7页Journal of Modern Medicine & Health

基　　金：云南省精神心理疾病临床医学研究中心专项基金课题(202102AA100058)。

摘　　要：目的通过双样本孟德尔随机化分析探讨炎症蛋白因子与抑郁症之间的因果关联。方法利用公开基因谱数据获得91种炎症蛋白因子及抑郁症的2种遗传基因数据,采用逆方差加权法(IVW)进行双样本孟德尔随机化分析。采用异质性检验、多效性检验、Leave-one-out检验进行敏感性分析,用比值比(OR)值及95%可信区间(95%CI)对炎症蛋白因子和抑郁症的因果关系进行解释。结果IVW提示炎症蛋白因子CD40受体(CD40L)与抑郁症的因果风险呈负相关(OR=0.999,95%CI 0.999~1.000,P=0.035)。炎症蛋白因子转化生长因子-α(TGF-α)与抑郁症的因果风险呈正相关(OR=1.001,95%CI 1.000~1.003,P=0.047)。结论通过双样本孟德尔随机化分析进一步阐述了91种炎症蛋白因子中CD40L、TGF-α与抑郁症之间存在因果关联。Objective To explore the causal relationship between inflammatory protein factors and depression by two-sample Mendelian randomization analysis.Methods The data of 91 inflammatory protein factors and two genetic genes of depression were obtained by using the public gene spectrum data,and the inverse variance weighting method(IVW)was used for two-sample Mendelian randomization analysis.Heterogeneity test,pleiotropic test,and Leave-one-out test were used for sensitivity analysis.The odds ratio(OR)value and 95%confidence interval(95%CI)were used to explain the causal relationship between inflammatory protein factors and depression.Results IVW suggested that the inflammatory protein factor CD40 receptor(CD40L)was negatively correlated with the causal risk of depression(OR=0.999,95%CI 0.999-1.000,P=0.035).Inflammatory protein factor transforming growth factor-α(TGF-α)was positively correlated with the causal risk of depression(OR=1.001,95%CI 1.000-1.003,P=0.047).Conclusion The causal relationship between CD40L,TGF-αand depression in 91 inflammatory protein factors are further elaborated by two-sample Mendelian randomization analysis.

关 键 词：孟德尔随机化 炎症蛋白因子 抑郁症 全基因组关联研究 单核苷酸多态性 工具变量 

分 类 号：R749.4[医药卫生—神经病学与精神病学]