老年偏头痛患者血清MnSOD、hs-CRP水平与认知功能的关系研究  

The relationship between serum MnSOD,hs-CRP levels and cognitive function in elderly patients with migraine

作　　者：代雪莲 刘海林 叶静纳 DAI Xuelian;LIU Hailin;YE Jingna(The Second Ward of Neurology,Luoyang Central Hospital Affiliated to Zhengzhou University,Luoyang,Henan 471000,China)

机构地区：[1]郑州大学附属洛阳中心医院神经内科二病区,河南洛阳471000

出　　处：《现代医药卫生》2025年第4期874-877,共4页Journal of Modern Medicine & Health

摘　　要：目的研究老年偏头痛患者血清锰超氧化物歧化酶(MnSOD)、超敏C反应蛋白(hs-CRP)水平与认知功能的关系。方法选取该院2023年1月至2024年1月收治的118例老年偏头痛患者进行试验,根据蒙特利尔认知评估(MoCA)评分分为认知功能正常组(MoCA≥26分)68例及认知功能障碍组(MoCA<26分)50例。比较2组患者相关基线资料,检测2组患者血清MnSOD、hs-CRP水平,logistic回归分析影响老年偏头痛患者认知功能的危险因素,通过受试者操作特征(ROC)曲线评估血清MnSOD、hs-CRP水平预测老年偏头痛患者认知功能障碍的价值。结果认知功能障碍组血清MnSOD水平低于认知功能正常组[(6.33±1.25)U/mL vs.(12.35±2.33)U/mL],hs-CRP高于认知功能正常组[(6.82±1.65)mg/L vs.(3.15±1.02)mg/L],差异均有统计学意义(P<0.05);经多因素logistic回归分析证实,血清MnSOD<7.410 U/mL、hs-CRP>4.032 mg/L均是影响老年偏头痛患者认知功能的危险因素(P<0.05);经过ROC曲线分析证实,血清MnSOD、hs-CRP均可用于预测老年偏头痛患者认知功能障碍,曲线下面积分别为0.980、0.973(P<0.05)。结论血清MnSOD水平的下降,hs-CRP水平的升高,可作为评估老年偏头痛患者认知功能障碍的重要参考指标。Objective To study the relationship between serum manganese superoxide dismutase(MnSOD),high-sensitivity C-reactive protein(hs-CRP)levels and cognitive function in elderly patients with migraine.Methods A total of 118 elderly migrainepatients admitted to the hospital from January 2023 to January 2024 were selected for the experiment.According to the Montreal Cognitive Assessment(MoCA)score,All patients were divided into normal cognitive function group(MoCA≥26 points,68 cases)and cognitive dysfunction group(MoCA<26 points,50 cases).The baseline data of the two groups were compared.The levels of serum MnSOD and hs-CRP were detected in the two groups.Logistic regression analysis was used to analyze the risk factors affecting cognitive function in elderly patients with migraine.The value of serum MnSOD and hs-CRP levels in predicting cognitive dysfunction in elderly patients with migraine was evaluated by receiver operator characte ristic(ROC)curve.Results The serum MnSOD level in the cognitive dysfunction group was lower than that in the normal cognitive function group[(6.33±1.25)U/mL vs.(12.35±2.33)U/mL],and the hs-CRP was higher than that in the normal cognitive function group[(6.82±1.65)mg/L vs.(3.15±1.02)mg/L],the differences were statistically significant(P<0.05).Multivariate logistic regression analysis confirmed that serum MnSOD<7.410 U/mL and hs-CRP>4.032 mg/L were risk factors affecting cognitive function in elderly patients with migraine(P<0.05).ROC curve analysis confirmed that serum MnSOD and hs-CRP could be used to predict cognitive dysfunction in elderly patients with migraine,and the area under the curve was 0.980 and 0.973,respectively(P<0.05).Conclusion The decrease of serum MnSOD level and the increase of hs-CRP level can be used as an important reference index to evaluate cognitive dysfunction in elderly patients with migraine.

关 键 词：老年 偏头痛 锰超氧化物歧化酶 超敏C反应蛋白 认知功能 

分 类 号：R747.2[医药卫生—神经病学与精神病学]