Dynamics of inflammatory signals within the tumor microenvironment  

作　　者：Hala Issa Lokjan Singh Kok-Song Lai Tina Parusheva-Borsitzky Shamshul Ansari 

机构地区：[1]Division of Health Sciences,Higher Colleges of Technology,Abu Dhabi 25026,United Arab Emirates [2]Department of Microbiology,Karnali Academy of Health Sciences,Jumla 21200,Karnali,Nepal

出　　处：《World Journal of Experimental Medicine》2025年第2期24-39,共16页世界实验医学杂志(英文)

摘　　要：Tumor stroma,or tumor microenvironment(TME),has been in the spotlight during recent years for its role in tumor development,growth,and metastasis.It consists of a myriad of elements,including tumor-associated macrophages,cancer-associated fibroblasts,a deregulated extracellular matrix,endothelial cells,and vascular vessels.The release of proinflammatory molecules,due to the inflamed microenvironment,such as cytokines and chemokines is found to play a pivotal role in progression of cancer and response to therapy.This review discusses the major key players and important chemical inflammatory signals released in the TME.Furthermore,the latest breakthroughs in cytokine-mediated crosstalk between immune cells and cancer cells have been highlighted.In addition,recent updates on alterations in cytokine signaling between chronic inflammation and malignant TME have also been reviewed.

关 键 词：Inflammatory signals Tumor microenvironment CYTOKINES INTERLEUKINS Transforming growth factor 

分 类 号：R730.2[医药卫生—肿瘤]