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作 者:John Bukasa-Kakamba Ayrton I Bangolo Shruti Wadhwani Pascal Bayauli Nikita Wadhwani Vignesh K Nagesh Maria J Mou Princejeet S Chahal Branly Mbunga Sindhuja Chindam Taieba Mushfiq Abhishek Thapa Nidhi L Rao Isis Kapinga Kalambayi Rahul Y Rajesh Ipek B Sarioguz Vishal KR Thoomkuntla Shamsul Arefin Navneet Kaur Manasse Bukasa Mutombo Satyajeet Singh Natalia Muto Surya Vamsi Pujita Mallampalli Aliocha Natuhoyila Nkodila Simcha Weissman Jean-RenéM'Buyamba-Kabangu
机构地区:[1]Department of Endocrinology and Metabolic Diseases,University of Kinshasa,Kinshasa 999069,Congo [2]Department of Endocrinology,Liege University Hospital Center,Liège 4000,Belgium [3]Department of Hematology and Oncology,John Theurer Cancer Center at Hackensack University Medical Center,Hackensack,NJ 07601,United States [4]Department of Internal Medicine,Hackensack Palisades Medical Center,North Bergen,NJ 07047,United States [5]Department of School of Public Health,University of Kinshasa,Kinshasa 999069,Congo [6]Department of Ophthalmology,Avignon Hospital Center,Avignon 84000,France [7]Department of Family Medicine and Primary Health Care,Protestant University of Congo,Kinshasa 999069,Congo [8]Department of Internal Medicine,University of Kinshasa,Kinshasa 999069,Congo
出 处:《World Journal of Experimental Medicine》2025年第2期109-120,共12页世界实验医学杂志(英文)
摘 要:BACKGROUND Several trace minerals have been shown to be associated with thyroid cancer.Democratic Republic of Congo(DRC)is deemed the most mineral-rich country globally.Data on the characteristics of thyroid nodules in various mineral-rich regions of the DRC is scarce.AIM To analyze the differential spectrum of thyroid nodules based on locoregional variance in mineral density.METHODS We conducted a cross-sectional study on 529 patients with thyroid nodules residing in Katanga,South Kivu and Kinshasa between 2005 and 2019.Of these three provinces,Katanga and South Kivu have the highest mineral density with the DRC.RESULTS Mean patient age was 44.2 years±14.6 years with a female predominance,with a female to male ratio of 5.4.The 66.5%of patients had a family history of thyroid disease.Total 74 patients had simple nodules,and the remaining 455 patients had multiple nodules.The 87.7%of patients were euthyroid.The nodules exhibited varying characteristics namely hypoechogenicity(84.5%),solid echostructure(72.2%),macronodular appearance(59.8%),calcifications(14.4%)and associated lymphadenopathy(15.5%).The 22.3%of the nodules were malignant.Factors independently associated with malignancy were older age(≥60 years)[adjusted odds ratio(aOR)=2.81],Katanga province(aOR=8.19),solid echostructure(aOR=7.69),hypoechogenicity(aOR=14.19),macronodular appearance(aOR=9.13),calcifications(aOR=2.6)and presence of lymphadenopathy(aOR=6.94).CONCLUSION Thyroid nodules emanating from the mineral-laden province of Katanga were more likely to be malignant.Early and accurate risk-stratification of patients with thyroid nodules residing in high-risk areas could be instrumental in optimizing survival in these patients.
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