Prevalence and genotype distribution of human papillomavirus among women with cervical or vaginal lesions in Jiangsu,China:2 cross-sectional studies(2012–2013 and 2020–2021)  

作　　者：Weiwei Han Wenjuan Wang Kai Chu Zhaofeng Bi Qi Chen Jingxin Li Fengcai Zhu 

机构地区：[1]School of Public Health,National Vaccine Innovation Platform,Nanjing Medical University,Nanjing,China [2]Jiangsu Provincial Medical Innovation Center,National Health Commission Key Laboratory of Enteric Pathogenic Microbiology,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing,China [3]State Key Laboratory of Vaccines for Infectious Diseases,Xiang An Biomedicine Laboratory,School of Public Health,Xiamen University,Xiamen,China [4]National Institute of Diagnostics and Vaccine Development in Infectious Diseases,State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,National Innovation Platform for Industry-Education Integration in Vaccine Research,NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology,Xiamen University,Xiamen,China

出　　处：《Oncology and Translational Medicine》2025年第2期50-57,共8页肿瘤学与转化医学(英文版)

基　　金：supported by Xiamen University,which played a key role in the collection and analysis of the data;funded by National Natural Science Foundation of China(grants 82341031,82173584,and 82222062);Major Research Plan of the National Natural Science Foundation of China(grant 92269205);Science Fund for Distinguished Young Scholars of Jiangsu Province(grant BK20220064);Jiangsu Provincial Key Project of Science and Technology Plan(grants BE2021738 and BE2023601)。

摘　　要：Background:Human papillomavirus(HPV)infection is a major risk factor of cervical cancer.This study assessed the prevalence and distribution of HPV genotypes in women with cervical or vaginal lesions in Jiangsu Province,China.Methods:A total of 2120 healthy women aged 18–45 years were screened between 2012 and 2013 and 6171 healthy women aged18–45 years were screened between 2020 and 2021 in Jiangsu Province.Cervical specimens collected from each woman were first tested using the HPV DNA enzyme immunoassay method,and positive samples were further tested using the reverse hybridization line probe assay.Differences in HPV prevalence and genotype distribution were compared between women with cervical and vaginal lesions identified during 2 rounds of cross-sectional screening.To account for differences in age composition between the 2 studies,the standardized prevalence of HPV positivity was calculated using the sum of the total number of women diagnosed with cervical or vaginal lesions during both periods as the standard group.Results:Overall,40 women(1.89%)were diagnosed with cervical or vaginal lesions through biopsy during 2012–2013,and 110(1.78%)were diagnosed during 2020–2021.Among women with lesions,the standardized HPV positivity rates were 98.41%in 2012–2013 and99.24%in 2020–2021.Most cases were caused by high-risk HPV,which accounted for 87.18%of the total infections during 2012–2013and 89.91%of those in 2020–2021,with standardized positivity rates of 86.44%and 88.75%,respectively.The standardized positivity rates for single infections were 62.35%in 2012–2013 and 74.95%in 2020–2021.The top 5 high-risk HPV genotypes were HPV type 16(HPV16;29.01%),52(20.63%),18(14.28%),58(13.71%),and 33(12.12%)in 2012–2013,and HPV16(36.95%),58(22.18%),52(13.25%),31(7.63%),and 51(6.81%)in 2020–2021.The standardized positivity rate for HPV18 decreased from 14.28%in2012–2013 to 1.15%in 2020–2021.Among women with cervical or vaginal lesions,the highest proportion was observed in the 36-to 45-year group

关 键 词：Cervical lesion Genotype distribution Human papillomavirus Jiangsu Province PREVALENCE Vaginal lesion 

分 类 号：R737.33[医药卫生—肿瘤]