Hedgehog信号通路磷酸化修饰在肿瘤发生发展中作用的研究进展  

Research progress in effect of phosphorylation modification of Hedgehog signaling pathway on occurrence and development of tumor

作　　者：张鑫 王飞 崔冰洁 杜静 ZHANG Xin;WANG Fei;CUI Bingjie;DU Jing(Medical Research Center,Affiliated Hospital,Binzhou Medical University,Binzhou 256603,China;Department of Hematology,First Clinical Medical College,Binzhou Medical University,Binzhou 256603,China)

机构地区：[1]滨州医学院附属医院医学研究中心,山东滨州256603 [2]滨州医学院第一临床医学院血液内科,山东滨州256603

出　　处：《吉林大学学报(医学版)》2025年第2期526-533,共8页Journal of Jilin University:Medicine Edition

基　　金：国家自然科学基金项目(82373097,31900441);山东省科技厅自然科学基金项目(ZR2019MC026);山东省卫健委中医药发展计划项目(2019-0514);泰山学者青年专家经费项目(tsqn202103191)。

摘　　要：Hedgehog (HH)信号通路参与脊椎动物和无脊椎动物的诸多发育过程,包括胚胎发生、干细胞更新、组织再生、肿瘤的发生发展及化疗耐药等。HH信号通路中关键组分的过度激活和异常表达与多种恶性肿瘤的发生发展有关。磷酸化修饰在正常细胞的蛋白质活性与功能调节中发挥重要作用,并且磷酸化-去磷酸化级联反应失调与肿瘤密切相关。HH信号通路的异常激活也与蛋白质磷酸化修饰有关,其调控的复杂机制还需进一步探索。本文对恶性肿瘤中HH信号通路以及蛋白磷酸化修饰的研究进展进行综述,重点讨论磷酸化修饰对HH信号通路活性的调控作用及其对恶性肿瘤发生发展的影响,以期为靶向磷酸酶/去磷酸酶药物的深入研发和临床应用提供理论基础。The Hedgehog(HH)signaling pathway is involved in various developmental processes of vertebrates and invertebrates,including embryogenesis,stem cell renewal,tissue regeneration,the occurrence and development of tumor and chemotherapy resistance.Overactivation and abnormal expression of key components in the HH signaling pathway are associated with the development of various malignant tumors.Phosphorylation plays an important role in regulating the activity and function of proteins in normal cells,and the disorder of phosphorylation-dephosphorylation cascade is closely related to tumorigenesis.The abnormal activation of this signaling pathway is also related to protein phosphorylation,while its complex underlying mechanism needs to be further explored.This article reviewed the research progress of the HH signaling pathway and protein phosphorylation modification in malignant tumors,focusing on the regulatory effect of phosphorylation modification on the activity of HH signaling pathway and its effect on the occurrence and development of malignant tumors,in order to provide a theoretical basis for the in-depth development and clinical application of targeted drugs for phosphatase/dephosphatase.

关 键 词：肿瘤 HEDGEHOG信号通路 蛋白磷酸酶 去磷酸化 

分 类 号：R730.2[医药卫生—肿瘤]