角膜缘干细胞种植术研究进展及应用前景  

Research on simple limbal epithelial transplantation and its application prospects

作　　者：王滢珲(综述) 接英(审校) Wang Yinghui;Jie Ying(Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Institute of Ophthalmology,Beijing Key Laboratory of Ophthalmology and Visual Science,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院,北京同仁眼科中心,北京市眼科研究所,北京市眼科学与视觉科学重点实验室,北京100730

出　　处：《中华实验眼科杂志》2025年第4期364-367,共4页Chinese Journal Of Experimental Ophthalmology

基　　金：国家自然科学基金(81970764);首都卫生研究与发展科研专项(2022-1-1081);北京市医院管理局登峰人才计划(1-1-1-2-301-1);青年北京学者(022);北京市高层次公共卫生技术人才建设项目;北京市属医学科研院所公益发展改革试点项目(PWD&RPP-MRI、JYY2023-6)。

摘　　要：外伤或疾病所致的角膜缘损伤可导致角膜缘干细胞缺乏(LSCD)。重度LSCD是临床诊疗中一类较为棘手的疾病,角膜缘干细胞移植术(LSCT)是其主要治疗方法。角膜缘干细胞种植术(SLET)是一种创新的LSCT技术。其手术方法是去除患眼表面的纤维血管翳,将供体眼的少量角膜缘上皮组织剪成微小组织块,使其上皮面朝上移植于受体患眼角膜表面,并以羊膜为载体修复眼表。通过术后定期随访可以发现,组织块不断扩张移行,并于术后2周左右完成角膜上皮化。与其他LSCT术式相比,SLET操作简单、取材少、可重复进行,且具有良好的临床应用前景,本文对SLET的研究进展进行综述。Damage to limbal due to injury or disease can lead to limbal stem cell deficiency(LSCD).Severe LSCD is difficult to diagnose and treat clinically,while limbal stem cell transplantation(LSCT)is the main treatment.Simple limbal epithelial transplantation(SLET)is a novel technique for LSCT.The procedure involves removing the fibrovascular pannus from the recipient eye,cutting the limbal tissue from the donor eye into tiny pieces,transplanting the epithelial side up onto the corneal surface of the recipient eye,and using amniotic membrane as a carrier to repair the ocular surface.Regular follow-up shows that the corneal epithelialization is completed at approximately two weeks postoperatively through the continuous expansion and migration of the tissue.Compared with other LSCT procedures,SLET is simple to perform,requires less biopsy,and has good repeatability.In addition,SLET has shown good clinical prospects.This article reviews the research progress of SLET.

关 键 词：角膜缘干细胞 角膜缘干细胞缺乏 角膜缘干细胞种植术 

分 类 号：R779.6[医药卫生—眼科]