变应性结膜炎动物造模研究进展  

Research progress in animal models of allergic conjunctivitis

作　　者：张佳讯(综述) 何宇茜[2] 张妍(审校) Zhang Jiaxun;He Yuxi;Zhang Yan(Bethune Second Clinical Medical College of Jilin University,Changchun 130041,China;Eye Center of the Second Hospital of Jilin University,Changchun 130022,China;Department of Ophthalmology,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China)

机构地区：[1]吉林大学白求恩第二临床医学院,长春130041 [2]吉林大学第二医院眼科中心,长春130022 [3]上海交通大学医学院附属第一人民医院眼科,上海200080

出　　处：《中华实验眼科杂志》2025年第4期378-384,共7页Chinese Journal Of Experimental Ophthalmology

基　　金：吉林省卫生健康科技能力提升项目(2021JC015);吉林省卫生专项项目(2020SCZT089、2020SCZT025);吉林省科技厅国际科技合作项目(20200801016GH);吉林大学青年师生交叉学科培育项目(2022-JCXK-28)。

摘　　要：变应性结膜炎发病率高,反复发作不易根治,严重影响人们的生活质量。动物模型是变应性结膜炎疾病研究的主要工具和手段,动物造模是变应性结膜炎疾病研究的重要步骤。由于变应性结膜炎的研究相对晚于其他变应性疾病,因此变应性结膜炎动物造模主要参考了变应性哮喘、变应性鼻炎等变应性疾病的动物造模方式,或在其基础上进行改进,致使动物造模方式多样化,动物造模方法可参考性差,并且动物造模的成活率和成功率较低。本文总结了变应性结膜炎的发病机制和动物造模目的,检索PubMed近10年文献中关于变应性结膜炎的动物造模方法,根据致敏机制对造模方法进行了梳理和分析,归纳出4种造模过程模型,为变应性结膜炎动物造模中动物品系选择、致敏剂量和致敏过程提供了参考。Allergic conjunctivitis has a high incidence rate,which is difficult to cure after repeated attacks,and seriously affects people's quality of life.Animal models are the main tools and means for the study of allergic conjunctivitis diseases,and animal modeling is an important step in the study of allergic conjunctivitis diseases.Because the study of allergic conjunctivitis is relatively late than that of other allergic diseases,the animal model of allergic conjunctivitis mainly refers to the animal model building methods of allergic asthma,rhinitis and other allergic diseases,or makes improvements on them,resulting in a variety of animal model building methods,poor reference of animal model building methods,and low survival rate and success rate of animal model building.This paper analyzes the pathogenic mechanism of allergic conjunctivitis and the purpose of animal modeling,searches and analyzes the modeling process of allergic conjunctivitis in Pubmed in the past 10 years,sorted and analyzed the modeling methods according to the sensitization mechanism,and summarized four modeling process models,which provided a reference for the selection of animal strains,sensitization dose and sensitization process in the modeling of allergic conjunctivitis.

关 键 词：变应性结膜炎 造模方法 动物模型 致敏细胞 

分 类 号：R777.2[医药卫生—眼科]