Structural and temporal dynamics analysis on immune response in low-dose radiation:History,research hotspots and emerging trends  

作　　者：Shu-Yuan Wang Jia-Xing Wu Xian An Zhen Yuan Yi-Fan Ren Xiu-Feng Yu Xiao-Dong Tian Wei Wei 

机构地区：[1]School of Medicine,Nankai University,Tianjin 300071,China [2]Senior Department of Oncology,The Fifth Medical Center of Chinese PLA General Hospital,Beijing 100853,China [3]Department of General Medicine,Tuberculosis Hospital of Shaanxi Province,Xi’an 710105,Shaanxi Province,China [4]Department of Thoracic Surgery,Chinese PLA General Hospital,Beijing 100853,China

出　　处：《World Journal of Radiology》2025年第4期32-46,共15页世界放射学杂志(英文)

摘　　要：BACKGROUND Radiotherapy(RT)is a cornerstone of cancer treatment.Compared with conven-tional high-dose radiation,low-dose radiation(LDR)causes less damage to normal tissues while potentially modulating immune responses and inhibiting tumor growth.LDR stimulates both innate and adaptive immunity,enhancing the activity of natural killer cells,dendritic cells,and T cells.However,the me-chanisms underlying the effects of LDR on the immune system remain unclear.AIM To explore the history,research hotspots,and emerging trends in immune response to LDR literature over the past two decades.METHODS Publications on immune responses to LDR were retrieved from the Web of Science Core Collection.Bibliometric tools,including CiteSpace and HistCite,were used to identify historical features,active topics,and emerging trends in this field.RESULTS Analysis of 1244 publications over the past two decades revealed a significant surge in research on immune responses to LDR,particularly in the last decade.Key journals such as INR J Radiat Biol,Cancers,and Radiat Res published pivotal studies.Citation networks identified key studies by authors like Twyman-Saint Victor C(2015)and Vanpouille-Box C(2017).Keyword analysis revealed hotspots such as ipilimumab,stereotactic body RT,and targeted therapy,possibly identifying future research directions.Temporal variations in keyword clusters and alluvial flow maps illustrate the evolution of research themes over time.CONCLUSION This bibliometric analysis provides valuable insights into the evolution of studies on responses to LDR,highlights research trends,and identifies emerging areas for further investigation.

关 键 词：Low-dose radiotherapy Immune response Immunotherapy Bibliometric analysis Radiation-induced immunogenicity Synergistic therapies 

分 类 号：R730.5[医药卫生—肿瘤]