Non-coding RNAs in adipose-derived stem cell exosomes:Mechanisms,therapeutic potential,and challenges in wound healing  

作　　者：Jian Rong Yao-Yao Li Xin Wang Jia-Ning Wang Mei Song 

机构地区：[1]Department of Burns and Plastic Surgery,The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army,Lanzhou 730050,Gansu Province,China [2]Department of Plateau Medicine,The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army,Lanzhou 730050,Gansu Province,China

出　　处：《World Journal of Stem Cells》2025年第4期6-19,共14页世界干细胞杂志(英文)

基　　金：Supported by the Intra-Hospital Project of No.940 Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army,No.2021yxky016.

摘　　要：The treatment of complex wounds presents a significant clinical challenge due to the limited availability of standardized therapeutic options.Adipose-derived stem cell exosomes(ADSC-Exos)are promising for their capabilities to enhance angiogenesis,mitigate oxidative stress,modulate inflammatory pathways,support skin cell regeneration,and promote epithelialization.These exosomes deliver noncoding RNAs,including microRNAs,long non-coding RNAs,and circular RNAs,which facilitate collagen remodeling,reduce scar formation,and expedite wound healing.This study reviews the mechanisms,therapeutic roles,and challenges of non-coding RNA-loaded ADSC-Exos in wound healing and identifies critical directions for future research.It aims to provide insights for researchers into the potential mechanisms and clinical applications of ADSC-Exos non-coding RNAs in wound healing.

关 键 词：Adipose-derived stem cell exosomes Wound healing MICRORNAS Long noncoding RNAs Circular RNAs 

分 类 号：R73[医药卫生—肿瘤]