Interplay of genetic and clinical factors in cancer-associated thrombosis:Deciphering the prothrombotic landscape of colorectal cancer  

作　　者：Duo-Gang Xu Jing Tan 

机构地区：[1]Department of General Surgery,Yan'an Hospital Affiliated to Kunming Medical University,Kunming 650051,Yunnan Province,China [2]Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province,Kunming 650051,Yunnan Province,China

出　　处：《World Journal of Gastroenterology》2025年第14期18-31,共14页世界胃肠病学杂志(英文)

摘　　要：Colorectal cancer(CRC),the third most prevalent cancer globally,exhibits a notable association with venous thromboembolism(VTE),significantly impacting patient morbidity and mortality.We delve into the complex pathogenesis of cancer-associated thrombosis(CAT)in CRC,highlighting the interplay of clinical risk factors and tumor-specific mechanisms.Our comprehensive review synthesizes the current understanding of CRC’s pro-thrombotic tendencies,examining both general clinical factors(e.g.,age,gender,obesity,prior VTE history)and tumor-specific aspects(e.g.,tumor location,stage,targeted therapies).Key findings illustrate how CRC cells themselves actively contribute to coagulation cascade activation through various procoagulant elements such as tissue factor,cancer procoagulant,and extracellular vesicles.We also explore how CRC influences host cells to adopt a procoagulant phenotype,thereby exacerbating thrombotic risks.This review underscores the role of genetic mutations in CRC(e.g.,KRAS,p53)in modulating coagulation-related protein expression and thrombosis risks.An in-depth understanding of the genetic landscape specific to CRC subtypes is essential for developing targeted anticoagulation strategies and could significantly advance thrombosis prevention while improving the overall management of patients with CRC.This highlights the urgent need for precision in addressing CAT within clinical settings.

关 键 词：Colorectal cancer cell Cancer-associated thrombosis Venous thromboembolism Tissue factor PLATELET 

分 类 号：R73[医药卫生—肿瘤]