Tired of the confusion around pleural effusions:Adenosine deaminase detection sets the record straight!  

作　　者：Kai-Yan Liu Xiao-Bing Li 

机构地区：[1]Department of Urology,Zhejiang Provincial People's Hospital,Hangzhou 310014,Zhejiang Province,China [2]Department of Thoracic Oncology,Hubei Cancer Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430079,Hubei Province,China

出　　处：《World Journal of Clinical Cases》2025年第21期1-5,共5页世界临床病例杂志(英文)

摘　　要：Pleural effusion,characterized by the accumulation of fluid in the pleural space,poses significant challenges in clinical practice,especially in determining whether it belongs to the inflammatory exudates or non-inflammatory transudates.Adenosine deaminase(ADA),an enzyme primarily produced by immune cells,particularly lymphocytes,increase in response to inflammatory conditions,including tuberculosis and malignancies.Elevated ADA levels in pleural have been shown to correlate with inflammatory exudates,making it a valuable biomarker for dif-ferentiating between inflammatory and non-inflammatory effusions.Moreover,numerous studies have demonstrated the treatment function of ADA in inflammation-related pleural effusion syndrome.Recently,research has established the values for the implication of ADA in diagnosing and managing pleural disease.Based on these findings,ADA becomes a reliable,non-invasive marker for early diagnosis and the appropriate treatment for pleural inflammation,ultimately improving patient outcomes.

关 键 词：Pleural effusion Pleural inflammation Diagnosis BIOMARKER Adenosine deaminase 

分 类 号：R561.3[医药卫生—呼吸系统]