CXCR4 expression and clinicopathological features of endometrial endometrioid carcinoma with the microcystic,elongated,and fragmented pattern  

作　　者：Ji-Xian Wang Dan-Hua Shen Xiao-Bo Zhang 

机构地区：[1]Department of Pathology,Peking University People’s Hospital,Beijing 100044,China

出　　处：《World Journal of Clinical Cases》2025年第21期25-33,共9页世界临床病例杂志(英文)

摘　　要：BACKGROUND The microcystic,elongated,and fragmented(MELF)pattern of invasion in endometrioid endometrial carcinoma(EEC)is a special mode of myometrial invasion that has been recently recognized by the pathology community.Overex-pression of CXC chemokine receptor 4(CXCR4)in tumor cells contributes to tumor growth,invasion,angiogenesis,metastasis,and recurrence.AIM To explore the correlation between CXCR4 expression in EEC and MELF invasion and clinicopathological features.METHODS A total of 205 EEC patients treated at Peking University People’s Hospital from June 2020 to December 2021 were selected(60 cases with MELF invasion,145 cases without).The clinicopathological features of the two groups were compared,and expression of CXCR4 protein,estrogen receptor,and progesterone receptor was detected and compared by immunohistochemistry.RESULTS EEC with MELF invasion was significantly associated with low tumor grade,lymphovascular space invasion,deep myometrial invasion,cervical stromal involvement,and lymph node metastasis.There was a difference in CXCR4 expression between the two groups,with the MELF group having a significantly higher expression than the non-MELF group.CONCLUSION CXCR4 expression is significantly increased in EEC with MELF invasion and in the MELF invasion area,which may promote tumor invasion and metastasis and has some value for prognostic assessment.

关 键 词：Endometrioid endometrial carcinoma Microcystic elongated and fragmented invasion CXCR4 Clinicopathological features PROGNOSIS 

分 类 号：R737.33[医药卫生—肿瘤]