Low salivary uric acid levels are independently associated with periodontitis  

作　　者：Leonardo Lorente Esther Hernández Marrero Pedro Abreu-Gonzalez Angel Daniel Lorente Martín Agustín F González-Rivero María JoséMarrero González Carmen Hernández Marrero Olga Hernández Marrero Alejandro Jiménez Cándido Manuel Hernández Padilla 

机构地区：[1]Intensive Care Unit,Hospital Universitario de Canarias,La Laguna 38320,Spain [2]Department of Periodontal,Clínica Dental Cándido,La Laguna 38204,Spain [3]Department of Basic Medical Sciences,University of La Laguna,La Laguna 38320,Spain [4]Department of Odontology,CEU San Pablo University,Madrid 28660,Spain [5]Department of Laboratory,Hospital Universitario de Canarias,La Laguna 38320,Spain [6]Research Unit,Hospital Universitario de Canarias,La Laguna 38320,Spain

出　　处：《World Journal of Clinical Cases》2025年第21期42-48,共7页世界临床病例杂志(英文)

摘　　要：BACKGROUND Lower salivary uric acid concentrations,the most abundant antioxidant agent in saliva,have been observed in patients with periodontitis compared to individuals with periodontal health.However,the independent association of salivary uric acid levels with periodontitis,accounting for other risk factors,as well as its association with periodontitis severity,has not been investigated.AIM To the independent association of salivary uric acid levels with periodontitis and the association of salivary uric acid levels with the severity of periodontitis.METHODS This observational and prospective study measured salivary uric acid levels in subjects with periodontitis(characterized by periodontal loss of tissue)and in subjects without periodontitis(periodontal health or localized gingivitis in<30%of sites).Multivariate regression analysis was performed to determine independent factors associated with periodontitis.Spearman’s rho correlation coefficient was used to assess the relationship between salivary uric acid levels and periodontitis severity.A receiver operating characteristic analysis was carried out to evaluate the diagnostic performance of salivary uric acid levels in periodontitis,reporting the area under curve(AUC)and its 95%CI.RESULTS We included 121 subjects,61 of them with periodontitis and 60 without periodontitis(39 with periodontal health and 21 with local gingivitis).Subjects with periodontitis compared to those without periodontitis were older(P<0.001),had higher salivary uric acid levels(P=0.002),higher rate of arterial hypertension history(P=0.001)and higher rate of never-smoker history(P<0.001).The AUC for periodontitis diagnosis by salivary uric acid levels was 66%(95%CI:57%-75%;P<0.001)and the better cut-off point was 111 nmol/mL.Multiple logistic regression analysis showed an independent association of salivary uric acid levels<111 nmol/mL(OR=6.14;95%CI:2.015-18.721;P=0.001)with periodontitis after controlling for age,never-smoker history and arterial hypertension.A negative correlation

关 键 词：OXIDATION SALIVARY Uric acid PERIODONTITIS GINGIVITIS 

分 类 号：R781.4[医药卫生—口腔医学]