Topical losartan for treating corneal haze after Pseudomonas keratitis:a case report  

作　　者：Fabrizio D’Ancona Pier Luigi Surico Rosario Alfio Umberto Lizzio Gabriele D’Ancona Luca Marelli Stefano Mattioli Paolo Nucci 

机构地区：[1]University of Milan,Eye Clinic,San Giuseppe Hospital,IRCCS Multimedica,Milan,Italy [2]Department of Sense Organs,Sapienza University,Rome,Italy [3]University Eye Clinic,San Giuseppe Hospital,IRCCS Multimedica,Milan,Italy [4]Department of Public Health and Infectious Diseases,Sapienza University of Rome,Rome,Italy [5]Department of Biomedical,Surgical and Dental Sciences,University of Milan,Milan,Italy

出　　处：《Annals of Eye Science》2025年第1期14-21,共8页眼科学年鉴(英文)

摘　　要：Background:Corneal scarring following bacterial keratitis,particularly from Pseudomonas infections,poses significant challenges in ophthalmic care.Current treatments often fall short in effectively reducing corneal haze and restoring vision.To our knowledge,this is the first report documenting the use of topical losartan,an angiotensin II receptor antagonist known to inhibit the transforming growth factor-β(TGF-β)pathway,for treating corneal haze resulting from bacterial keratitis.Case Description:A 30-year-old male presented with a persistent corneal scar in his right eye,178 days post-Pseudomonas keratitis.Despite a prolonged course of topical corticosteroids,his best-corrected visual acuity(BCVA)stabilized at 20/40 with a hybrid contact lens over a 2-month period.Given the lack of improvement,we initiated treatment with topical losartan at a concentration of 0.8 mg/mL,administered six times daily.After 4 months of therapy,the patient’s BCVA improved to 20/25.Slit-lamp examination and corneal tomography revealed a significant reduction in corneal haze,indicating a positive response to the treatment.Conclusions:This case suggests that topical losartan may be a promising therapeutic option for reducing corneal opacity following bacterial keratitis by inhibiting the TGF-βpathway.However,further clinical studies are necessary to confirm its efficacy and safety in broader patient populations.

关 键 词：Pseudomonas kerititis corneal scar HAZE topical losartan case report 

分 类 号：R772.21[医药卫生—眼科]