腹水回输联合臭氧治疗难治性肝硬化腹水的临床研究  

Clinical study of ascites reinfusion combined with ozone therapy for refractory liver cirrhosis

作　　者：张亚军 涂传涛 ZHANG Yajun;TU Chuantao(Department of Gastroenterology,Shanghai Public Health Clinical Center,Shanghai 201508,China)

机构地区：[1]上海市公共卫生临床中心消化科,上海201508

出　　处：《胃肠病学和肝病学杂志》2025年第3期390-393,共4页Chinese Journal of Gastroenterology and Hepatology

基　　金：上海市公共卫生临床中心科研启动基金(KW-GW-2021-34)。

摘　　要：目的分析腹水回输联合臭氧治疗难治性肝硬化腹水相比于单纯腹水回输治疗是否会更加有效,为难治性肝硬化腹水的治疗提供参考。方法选取2021年1月至2023年7月就诊于我院并需要进行腹水回输治疗的难治性肝硬化腹水患者,参与研究的患者需在观察期内进行腹水回输治疗和腹水回输联合臭氧治疗各1次,收集患者的临床资料及问卷调查结果并进行分析。结果两次治疗期间患者的白蛋白输注频率、肝功能、肾功能、电解质水平等差异均无统计学意义(P>0.05);治疗后第1天ASI-7评分及治疗前和治疗后第1天CLDQ评分两组间差异均无统计学意义(P>0.05);两次治疗前与治疗后第1天腹部症状(abdominal symptom,AS)、CLDQ、ASI-7之间差异有统计学意义(P<0.001);治疗后第7天两组间AS、CLDQ、ASI-7差异有统计学意义(P<0.001)。结论相较于单纯腹水回输治疗,腹水回输联合臭氧治疗难治性肝硬化腹水能改善患者的腹水症状,延长腹水消退稳定时间,增强治疗效果,在一定程度上减少治疗次数,提高患者的生存率和生活质量。Objective To analyze whether ascites reinfusion combined with ozone is more effective than ascites reinfusion alone in the treatment of refractory liver cirrhosis,and to provide a reference for the treatment of ascites in refractory liver cirrhosis.Methods Patients with refractory ascites due to liver cirrhosis who visited our hospital from Jan.2021 to Jul.2023 and required ascitic fluid reinfusion therapy were selected.Participants in the study underwent both ascitic fluid reinfusion therapy and ascitic fluid reinfusion combined with ozone therapy once during the observation period.Clinical data and questionnaire survey results were collected and analyzed.Results There were no statistically significant differences in albumin infusion frequency,liver function,renal function,and electrolyte levels between the two treatments(P>0.05),and there was no significant difference in ASI-7 score on the first day after treatment and CLDQ score between the two groups before treatment and on the first day after treatment(P>0.05).There were statistically significant differences in abdominal symptom(AS),CLDQ and ASI-7 between the two treatments before and on the first day after treatment(P<0.001),and there were significant differences in AS,CLDQ and ASI-7 between the two groups on the seventh day after treatment(P<0.001).Conclusion Compared with ascites reinfusion therapy alone,ascites reinfusion combined with ozone therapy for refractory liver cirrhosis can improve the symptoms of ascites,prolong the time for ascites to subside and stabilize,enhance the treatment effect,reduce the number of treatments to a certain extent,and improve the survival rate and quality of life.

关 键 词：腹水回输 臭氧治疗 难治性肝硬化腹水 

分 类 号：R575[医药卫生—消化系统]