肝纤维化和其他器官纤维化的药物治疗  

Therapeutic medicinals of hepatic fibrosis and fibrosis of other organs

作　　者：巫协宁[1] WU Xiening(Department of Gastroenterology,IBD Research Center,First People′s Hospital,Affiliated to Shanghai Jiao Tong University,School of Medicine,Shanghai 200080,China)

机构地区：[1]上海交通大学医学院附属上海市第一人民医院消化科炎症性肠病研究中心,上海200080

出　　处：《胃肠病学和肝病学杂志》2025年第3期418-419,共2页Chinese Journal of Gastroenterology and Hepatology

摘　　要：活化的肝星状细胞是肝纤维化的核心因素,它可激活TGF-β1使肝星状细胞分泌Ⅰ型、Ⅲ型、Ⅳ型及Ⅴ型胶原,这些是肝纤维化的基本组织结构,非酒精性脂肪性肝病的纤维化不同于慢性乙型肝炎的肝纤维化,有瘦素的参与。治疗最有效的药物是积雪草,已被广泛应用于肝、肺、肾、皮肤肌肉的纤维化。治疗纤维化有效的成分有积雪草苷等。它抑制多个信号通路和多个靶标,包括TGF-β1/Smad、MAPK、PDGF等信号通路,文内有详细的阐述。Activated hepatic stellate cells play a crucial role in hepatic fibrosis,these can also activate transforming growth factor-β1(TGF-β1)which enable the HSC to secrete typeⅠ,Ⅲ,ⅣandⅤcollagen to form the basic tissue structure of hepatic fibrosis.In non-alcoholic steatohepatitis,leptin also participates in its fibrogenesis.The most effective therapeutic drug is Centella asiatica which has been extensively used in treatment of hepatic,pulmonary,renal and dermato-myo fibrosis,its active component is Asiaticoside which inhibits several signal pathways and multiple targets,including TGF-β1/Smad signal pathway and MAPK,PDGF signal pathways etc.as well,even the skin scar formation can be effectively treated.

关 键 词：肝纤维化 肺纤维化 肾纤维化 皮肤肌肉纤维化 治疗药物 积雪草 积雪草苷 姜黄素 

分 类 号：R57[医药卫生—消化系统]