经内镜黏膜下剥离术后诊断大肠黏膜相关淋巴组织结外边缘区淋巴瘤2例报道  

Two cases extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue was diagnosed after endoscopic submucosal dissection

作　　者：宋淳 梁俊荣 吕丹丹 康林 刘震雄 窦维佳 SONG Chun;LIANG Junrong;LYU Dandan;KANG Lin;LIU Zhenxiong;DOU Weijia(Department of Gastroenterology,the Second Affiliated Hospital of Air Force Medical University,Xi′an 710038,China)

机构地区：[1]空军军医大学第二附属医院消化内科,陕西西安710038

出　　处：《胃肠病学和肝病学杂志》2025年第3期462-464,共3页Chinese Journal of Gastroenterology and Hepatology

基　　金：陕西省重点研发计划项目(2021SF-182);空军军医大学临床研究项目(2022LC2231)。

摘　　要：回顾性分析2022年6月至2023年6月于空军军医大学第二附属医院因大肠黏膜下隆起,经超声内镜(endoscopic ultrasonography,EUS)诊断为神经内分泌肿瘤(neuroendocrine tumor,NET),后经内镜黏膜下剥离术(endoscopic submucosal dissection,ESD)治疗后确诊为黏膜相关淋巴组织结外边缘区(extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue,EMZL/MALT)淋巴瘤2例患者的病历资料。通过分析患者EUS、治疗方式及随访情况等,关注ESD对大肠EMZL/MALT淋巴瘤的诊断治疗作用,减少误诊及漏诊。2例患者中,男1例,女1例,年龄分别为53岁、67岁。2例患者均为体检发现大肠隆起性病变,EUS提示NET,成功实施ESD治疗,术后病理均提示EMZL/MALT淋巴瘤。男性患者术后未行外科手术及全身放化疗等相关治疗,随访9个月,未转移复发。女性患者术后于血液科行直肠区域放射治疗,随访6个月,未转移复发。A retrospective analysis was made of neuroendocrine tumor(NET)diagnosed by endoscopic ultrasonography(EUS)in the Second Affiliated Hospital of Air Force Medical University from Jun.2022 to Jun.2023 due to the large intestinal submucosal lesions.The lesions were finally diagnosed with extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue(EMZL/MALT)lymphoma after endoscopic submucosal dissection(ESD).By analyzing EUS,treatment methods and follow-up of the lesions,the diagnostic and therapeutic effects of ESD on large intestine EMZL/MALT lymphoma were be focused on in order to reduce misdiagnosis and missed diagnosis.There were two patients,one male of 53 years old and one female of 67 years old,respectively.The large intestine protrusion lesions were found in both patients by physical examination,which were indicated NET by endoscopic,then ESD was successfully implemented.The postoperative pathological diagnosis of both lesions was EMZL/MALT lymphoma.The male patient,who did not receive further surgery or systemic chemoradiotherapy,had no metastasis or recurrence after 9 months of follow-up.The female patient,who underwent further rectal radiotherapy in the hematology department after ESD,was followed up for 6 months without metastasis or recurrence.

关 键 词：误诊及漏诊 大肠黏膜下隆起 大肠EMZL/MALT淋巴瘤治疗 

分 类 号：R574[医药卫生—消化系统]