循环肿瘤细胞自我种植在恶性肿瘤进展中的研究现状  

Research status of self-seeding by circulating tumor cells in tumor progression

作　　者：戴振霖 徐駸[1] DAI Zhenlin;XU Qin(Department of Oral and Maxillofacial-Head and Neck Oncology,Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai Key Laboratory of Stomatology&Shanghai Research Institute of Stomatology,National Clinical Research Center for Oral Disease,Shanghai 200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科,上海市口腔医学重点实验室,上海市口腔医学研究所,国家口腔疾病临床医学研究中心,200011上海

出　　处：《口腔颌面外科杂志》2025年第2期87-90,共4页Journal of Oral and Maxillofacial Surgery

基　　金：国家自然科学基金(81772871)。

摘　　要：自我种植是循环肿瘤细胞(circulating tumor cells,CTCs)的一种特殊生物学行为,其广泛存在于诸多恶性肿瘤中,并与肿瘤进展密切相关。目前多数研究着重于关注CTCs与肿瘤远处转移的内在联系,而对肿瘤自我种植现象的发生机制及生物学影响认识尚浅。本文针对CTCs通过自我种植在肿瘤进展中发挥的作用进行综述,为探究恶性肿瘤的进展机制提供新视角。Self-seeding,a distinct biological behavior of circulating tumor cells(CTCs),is prevalent in many malignant tumors and closely linked to tumor progression.While most research focuses on the relationship between CTCs and distant metastasis,the understanding of the biological impact of CTCs self-seeding on tumor initiation and local progression remains limited.This article reviews the role of CTCs in tumor progression via self-seeding,providing a new perspective for exploring the mechanisms underlying malignant tumor development.

关 键 词：循环肿瘤细胞 自我种植 肿瘤进展 

分 类 号：R782[医药卫生—口腔医学] R739.8[医药卫生—临床医学]