仿生结构理念在骨组织工程支架构建中的应用  

Application of biomimetic structural concept in bone tissue engineering scaffolds

作　　者：王云 王佐林[1] WANG Yun;WANG Zuolin(Shanghai Engineering Research Center of Tooth Restoration and Regeneration&Tongji Research Institute of Stomatology&Department of Oral Implantology,Shanghai Tongji Stomatological Hospital and Dental School,Tongji University,Shanghai 200072,China)

机构地区：[1]上海市同济口腔医院口腔种植科,同济大学口腔医学院,上海牙组织修复与再生工程技术研究中心,同济大学口腔医学研究所,上海200072

出　　处：《口腔颌面外科杂志》2025年第2期142-144,共3页Journal of Oral and Maxillofacial Surgery

基　　金：国家重点研发计划(2018YFE0202202,2018YFE0202200)。

摘　　要：骨组织工程(bone tissue engineering,BTE)支架的成分、孔径、孔隙率、机械性能等对骨再生的影响已被广泛研究。然而,目前关于其多尺度结构设计影响骨再生的研究仍不充分。基于仿生技术的发展,通过模仿天然材料的多尺度结构来改善BTE支架的机械性能和生物学活性以促进骨再生,是一种有前景的策略。因此,本文综述了近年来仿生结构材料在BTE支架中的研究进展,并讨论了未来发展的机遇和挑战,旨在为设计出性能更优越的BTE支架提供灵感。The influence of component composition,pore size,porosity,and mechanical properties of bone tissue engineering(BTE)scaffolds on bone regeneration has been extensively studied.However,there is currently a lack of research on the impact of multi-scale structural design on bone regeneration.With the advancement of biomimetic technology,mimicking the multiscale structures of natural materials presents a promising strategy to enhance the mechanical performance and biological activity of BTE scaffolds and facilitate bone regeneration.As such,this review provides a summary of recent advances in biomimetic structural materials utilized in BTE scaffolds,discussing future development opportunities and challenges with the aim of inspiring the design of BTE scaffolds with superior properties.

关 键 词：骨组织工程 骨组织工程支架 骨再生 仿生结构材料 

分 类 号：R782[医药卫生—口腔医学]