以中线对称口腔溃疡为主要症状的鼻型结外NK/T细胞淋巴瘤1例报告及文献复习  

Extranodal NK/T-cell lymphoma of nasal type with midline symmetry oral ulcer as the main symptom:A case report and literature review

作　　者：于栋林 曹璋[2] 王文龙 马向瑞 唐娟 左金华[1] YU Donglin;CAO Zhang;WANG Wenlong;MA Xiangrui;TANG Juan;ZUO Jinhua(Department of Oral and Maxillofacial Surgery,Binzhou Medical University Hospital,Binzhou 256600;Department of Pathology,Binzhou Medical University Hospital,Binzhou 256600;Binzhou Medical University,Binzhou 256603,China)

机构地区：[1]滨州医学院附属医院口腔颌面外科,滨州256600 [2]滨州医学院附属医院病理科,滨州256600 [3]滨州医学院,滨州256603

出　　处：《口腔颌面外科杂志》2025年第2期157-159,共3页Journal of Oral and Maxillofacial Surgery

基　　金：山东省自然科学基金(ZR2019PH075,ZR2018BH026);山东省医药卫生科技发展计划面上项目(2017WS231);山东省中医药科技青年项目(2020Q062)。

摘　　要：目的:探讨鼻型结外NK/T细胞淋巴瘤(extranodal NK/T-cell lymphoma of nasal type,ENKTL-NT)的临床病理特点、诊断及治疗,为临床医生的诊治提供参考。方法:报告1例以上腭黏膜呈中线对称溃疡为主要症状的ENKTL-NT病例,并结合文献进行讨论分析。结果:于我院多次活检明确诊断后,通过联合治疗,患者病情明显好转,术后随访9个月,患者死亡。结论:ENKTL-NT在临床上较少见且临床特征复杂,即使结合组织活检往往也难以明确诊断。对于长期不愈的口腔溃疡应保持高度警惕,推荐采用多处重复活检策略以提升诊断准确性。Objective:To investigate the clinicopathological features,diagnosis and treatment of extranodal NK/T-cell lymphoma of nasal type(ENKTL-NT),and to provide reference for the diagnosis and treatment of clinicians.Methods:A case of palatal mucosa with a midline symmetry ulcer was followed up and ENKTL-NT was discussed,and analyzed in combination with literature.Results:After multiple biopsies were taken and the diagnosis was confirmed,the patient's condition was obviously improved by combined treatment.During nine months of postoperative follow-up,the patient died.Conclusion:ENKTL-NT is rare for stomatologists,and its clinical features are complex.Biopsy is often difficult to confirm the diagnosis.It is necessary to implement repeated multi-site biopsy strategies to improve diagnostic accuracy.

关 键 词：鼻型结外NK/T细胞淋巴瘤 口腔溃疡 诊治 

分 类 号：R782[医药卫生—口腔医学]