Reduced choroidal vascular index and choroid structural changes extended beyond subfoveal area in chronic central serous chorioretinopathy eyes with macular neovascularization  

作　　者：Xiang-Gui Zhang Zhen-De Deng Yan-Nian Hui Zhen Huang Ya Ye Ming Yan Yan-Ping Song 

机构地区：[1]The First School of Clinical Medicine,Southern Medical University,Guangzhou 510515,Guangdong Province,China [2]Department of Ophthalmology,General Hospital of Central Theater Command,Wuhan 430070,Hubei Province,China [3]Department of Ophthalmology,Xijing Hospital,Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2025年第5期853-859,共7页国际眼科杂志(英文版)

基　　金：Supported by General Program of National Natural Science Foundation of China(No.82471110);National Key Research and Development Program of China(No.2022YFC2502805);Postdoctoral Foundation of General Hospital of Central Theater Command(No.20210517KY04).

摘　　要：AIM:To investigate the choroidal vascular index(CVI)and the choroidal structural changes beyond the subfoveal area(analyzed across a 20 mm×24 mm scanning area)in eyes with chronic central serous chorioretinopathy(cCSC)eyes with macular neovascularization(MNV)using ultra-widefield swept-source optical coherence tomography angiography(UWF SS-OCTA).METHODS:This retrospective comparative study included 46 cCSC with MNV eyes(With MNV group),52 cCSC without MNV eyes(Without MNV group),and 40 age-matched healthy controls.UWF SS-OCTA imaging with a 20 mm×24 mm protocol was used to quantify CVI across 9 subfields(superotemporal,superior,superonasal,temporal,central,nasal,inferotemporal,inferior,and inferonasal).The CVI was compared among the groups.RESULTS:With MNV group demonstrated significantly older mean age than Without MNV group(56.2±6.1 vs 47.5±8.6y,P<0.001).The CVI was significantly lower in the With MNV group than in the Without MNV group,except in the superotemporal,superior,and temporal regions(all P<0.05).Notably,despite MNV-associated CVI reductions,the With MNV group maintained a higher CVI than the control group in all 5 subfields(superior,temporal,central,inferior,and inferonasal;all P<0.05).In the central region,CONCLUSION:CVI decreases,and choroidal structural changes extend beyond the subfoveal area in cCSC with MNV eyes,providing with an imaging evidence for the important role of choroidal ischemia in the pathogenesis of MNV in cCSC.

关 键 词：central serous chorioretinopathy macular neovascularization choroidal vascular index choroidal thickness optical coherence tomography angiography 

分 类 号：R774.1[医药卫生—眼科]