乳腺癌发展中脂质代谢重编程的调控机制研究进展  

Advances in the study of the role of lipid metabolic reprogramming in regulating breast cancer development

作　　者：朱凯丽 曹梦悦 党永霞 令晓玲[2] ZHU Kaili;CAO Mengyue;DANG Yongxia;LING Xiaoling(The First Clinical Medical School,Lanzhou University,Lanzhou 730000,China;Ward 1,Department of Oncology,The First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]兰州大学第一医院肿瘤科一病区,甘肃兰州730000

出　　处：《兰州大学学报(医学版)》2025年第3期1-7,共7页Journal of Lanzhou University(Medical Sciences)

基　　金：甘肃省科技计划重点研发项目(23YFFA0035);甘肃省自然科学基金项目(21JR11R076);兰州市科技发展指导性计划项目(2019-ZD-42);甘肃省兰州市城关区科学技术局基金项目(2021SHFZ0006);“新锐肿瘤支持治疗课题研究”公益项目(cphcf-2022-013)。

摘　　要：乳腺癌是女性发病率和死亡率最高的恶性肿瘤,脂质代谢重编程可以有效调节肿瘤代谢程序,以满足肿瘤细胞增殖、侵袭、转移时的能量需求。本文以脂质代谢在肿瘤进展中的驱动作用为出发点,详细阐述了脂肪酸和胆固醇合成、吸收与氧化促进乳腺癌进展的具体机制,以及肿瘤微环境中基质细胞脂质代谢重编程与肿瘤细胞相互作用诱导其异常行为的潜在机制,并探讨了未来可能靶向脂质代谢信号通路的抗肿瘤治疗新策略。Breast cancer is the malignant tumor with the highest morbidity and mortality rate among women,and reprogramming lipid metabolism would effectively regulate tumor metabolic programs to meet the energy demands of tumor cells during proliferation,invasion and metastasis.Starting from the driving role of lipid metabolism in tumor progression,this paper has detailed the specific mechanisms by which fatty acid and cho-lesterol synthesis,uptake and oxidation promote breast cancer progression,as well as the potential mecha-nisms by which lipid metabolic reprogramming of stromal cells in the tumor microenvironment interacts with tumor cells to induce aberrant behaviors in tumor cells,and explored possible future novel antitumor therapeu-tic strategies targeting the lipid metabolic signaling pathway,either alone or in combination.It also explored new strategies for future antitumor therapy that may target lipid metabolism signaling pathways,either alone or in combination.

关 键 词：脂质代谢 乳腺癌 肿瘤微环境 靶向治疗 

分 类 号：R737.9[医药卫生—肿瘤]