10种中成药联合FOLFOX治疗中晚期结直肠癌有效性及安全性网状meta分析  

Efficacy and safety of 10 Chinese patent medicines combined with FOLFOX in the treatment of advanced colorectal cancer:a network meta-analysis

在线阅读下载全文

作  者:王明星 董皖辉 孙庆明 吴功义 WANG Mingxing;DONG Wanhui;SUN Qingming;WU Gongyi(Lu'an Hospital of Traditional Chinese Medicine Affiliated to Anhui University of Chinese Medicine,Lu'an 237005,China)

机构地区:[1]安徽中医药大学附属六安市中医院,安徽六安237005

出  处:《空军军医大学学报》2025年第4期474-482,共9页Journal of Air Force Medical University

基  金:安徽省高等学校科学研究项目(2023AH050834)。

摘  要:目的采用网状meta分析方法,对中成药联合FOLFOX治疗晚期肠癌的疗效和安全性进行深入比较。方法系统检索中国知网、万方、PubMed、Cochrane Library、维普、中国生物医学文献数据库、Embase、Web of Science八大数据库自建库至2023年10月20日所收录的中成药联合FOLFOX治疗中晚期结直肠癌的随机对照试验。采用RevMan、Stata 16.0软件分析数据。结果共纳入35项研究,涉及2982例中晚期结直肠癌患者,网状meta分析结果显示:在提高结直肠癌客观缓解率(ORR)方面,中成药排名前3为养正消积胶囊>消癌平>康艾注射液;在提高疾病控制率(DCR)方面,中成药排名前3为养正消积胶囊>复方斑蝥胶囊>消癌平;在改善结直肠癌患者生活质量(QOL)方面,中成药排名前3为养正消积胶囊>消癌平>艾迪注射液;在改善结直肠癌患者化疗后白细胞计数(WBC)下降方面,华蟾素胶囊>参一胶囊>复方斑蝥胶囊;在改善结直肠癌患者化疗后恶心呕吐发生率方面,华蟾素胶囊>养正消积胶囊>康艾注射液;在改善免疫功能方面,养正消积胶囊>复方斑蝥胶囊>康艾注射液。结论在常规化疗的基础上,联合这10种中成药可以提高中晚期结直肠癌患者的DCR、ORR和QOL,同时改善患者的免疫功能,降低因化疗引起的不良反应。其中,在提高ORR、DCR和QOL方面,养正消积胶囊表现最佳。在化疗后改善WBC下降和恶心呕吐方面,华蟾素胶囊表现最佳。在改善患者免疫功能方面,养正消积胶囊同样表现出色。Objective To compare the efficacy and safety of Chinese patent medicine combined with FOLFOX in the treatment of advanced colorectal cancer by network meta-analysis.Methods The randomized controlled trials of Chinese patent medicine combined with FOLFOX in the treatment of intermediate and advanced colorectal cancer included in databases of CNKI,WanFang Data,PubMed,Cochrane Library,VIP,CBM,Embase and Web of Science were systematically searched from the establishment of these databases to October 20,2023.The data were analyzed by RevMan and Stata 16.0 software.Results A total of 35 studies were included,involving 2982 patients with advanced colorectal cancer.The results of network meta-analysis showed that in terms of improving the objective response rate(ORR)of colorectal cancer,the top 3 Chinese patent medicines were Yangzheng Xiaoji Capsule>Xiaoaiping>Kangai Injection;in terms of improving disease control rate(DCR),the top 3 Chinese patent medicines were Yangzheng Xiaoji Capsule>Fufang Banmao Capsule>Xiaoaiping;in terms of improving the quality of life(QOL)of patients with colorectal cancer,the top 3 Chinese patent medicines were Yangzheng Xiaoji Capsule>Xiaoaiping>Aidi Injection;in terms of improving white blood cell count(WBC)decrease in patients with colorectal cancer after chemotherapy,the ranking of Chinese patent medicines was Cinobufotalin Capsule>Shenyi Capsule>Fufang Banmao Capsule;in terms of improving the incidence of nausea and vomiting in patients with colorectal cancer after chemotherapy,the ranking of Chinese patent medicines was Cinobufotalin Capsule>Yangzheng Xiaoji Capsule>Kangai Injection;and in terms of improving immune function,the ranking of Chinese patent medicines was Yangzheng Xiaoji Capsule>Fufang Banmao Capsule>Kangai Injection.Conclusion The combination of these 10 kinds of Chinese patent medicines on the basis of conventional chemotherapy can improve the DCR,ORR and QOL of patients with advanced colorectal cancer,enhance patients'immune function and reduce adverse reactions caused b

关 键 词:中晚期结直肠癌 网状meta分析 随机对照实验 中成药 FOLFOX 

分 类 号:R735.3[医药卫生—肿瘤]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象