CD8^(+)T细胞耗竭在肿瘤免疫逃逸中的表观重编程机制及干预策略  

Epigenetic reprogramming mechanisms and intervention strategies of CD8^(+)T cell exhaustion in tumor immune escape

作　　者：张慧洁 王丹 蒋建利 陈志南 李一鸣 ZHANG Huijie;WANG Dan;JIANG Jianli;CHEN Zhinan;LI Yiming(National Translational Science Center for Molecular Medicine,Department of Cell Biology,School of Basic Medical Sciences,Air Force Medical University,Xi'an 710032,China)

机构地区：[1]空军军医大学国家分子医学转化中心,基础医学院细胞生物学教研室,陕西西安710032

出　　处：《空军军医大学学报》2025年第4期556-560,共5页Journal of Air Force Medical University

基　　金：国家自然科学基金(82403382)。

摘　　要：肿瘤免疫治疗当前已成为肿瘤临床治疗的一大利器。然而,免疫逃逸是制约肿瘤免疫治疗疗效的瓶颈问题,导致肿瘤免疫逃逸的关键环节之一是CD8^(+)T细胞耗竭。研究表明,CD8^(+)T细胞在肿瘤微环境各种免疫抑制性因素的作用下发生表观重编程,导致CD8^(+)T细胞耗竭。如何有效靶向调节表观重编程机制抑制CD8^(+)T细胞耗竭,是目前亟待解决的重点和难点问题。本文综述了肿瘤微环境CD8^(+)T细胞耗竭的特征以及在肿瘤免疫逃逸中的表观重编程机制,并阐明了靶向调节表观遗传机制改善CD8^(+)T细胞耗竭的策略,旨在为肿瘤免疫治疗提供新思路、开辟新路径。At present,tumor immunotherapy has become a powerful weapon in clinical tumor treatment.However,immune escape is a bottleneck that restricts the efficacy of tumor immunotherapy,and CD8^(+)T cell exhaustion is one of the crucial causes in tumor immune escape.Researches have shown that CD8^(+)T cells undergo epigenetic reprogramming under the influence of various immunosuppressive factors in the tumor microenvironment,which leads to CD8^(+)T cell exhaustion.How to effectively target and regulate epigenetic reprogramming mechanisms to inhibit CD8^(+)T cell exhaustion is currently a key and difficult problem that needs to be solved urgently.This paper reviews the characteristics of CD8^(+)T cell exhaustion in the tumor microenvironment and epigenetic reprogramming mechanisms in tumor immune escape.It also elucidates the strategies for improving CD8^(+)T cell exhaustion through targeted regulation of epigenetic mechanisms,and aims to provide new ideas and open up new pathways for tumor immunotherapy.

关 键 词：T细胞耗竭 表观重编程 肿瘤免疫逃逸 

分 类 号：R730.51[医药卫生—肿瘤]