超重或肥胖儿童青少年抑郁障碍患者高尿酸血症患病率及影响因素分析  

Prevalence and influencing factors of hyperuricemia in overweight or obese children and adolescents with depressive disorder

作　　者：孙娜娜 刘志伟 孙亮 杨荣春[2] 刘云[2] SUN Na-na;LIU Zhi-wei;SUN Liang;YANG Rong-chun;LIU Yun(Affiliated Psychological Hospital of Anhui Medical University,Hefei 230022,China)

机构地区：[1]安徽医科大学附属心理医院,合肥市第四人民医院精神科,230022 [2]阜阳市第三人民医院精神科

出　　处：《临床精神医学杂志》2025年第2期98-101,共4页Journal of Clinical Psychiatry

基　　金：安徽省卫生健康委科研项目(AHWJ2021a035);阜阳市卫生健康委科研项目(FY2021-059)。

摘　　要：目的:探索超重或肥胖儿童青少年抑郁障碍患者高尿酸血症(hyperuricemia,HUA)患病率及影响因素。方法:纳入2020年1月至2021年12月阜阳市第三人民医院符合《国际疾病分类(第10版)》抑郁障碍诊断标准的196例儿童青少年住院患者,收集一般人口学资料及临床数据。采用相关性及逻辑回归分析探讨抑郁障碍患者血尿酸水平、HUA及其相关影响因素。结果:超重或肥胖青少年抑郁障碍患者HUA患病率为35.20%(69/196)。HUA与住院次数、体质量指数(body mass index,BMI)水平、总胆固醇、低密度脂蛋白胆固醇、血肌酐、自杀意念及抗抑郁药种类均相关(P均<0.05)。回归分析指出,高水平BMI、血肌酐及伴自杀意念均为超重或肥胖抑郁障碍青少年伴HUA的独立影响因素(P均<0.05)。结论:超重或肥胖儿童青少年抑郁障碍住院患者HUA患病率较高,且与高水平BMI、血肌酐及自杀意念密切相关。Objective:To explore the prevalence and influencing factors of hyperuricemia(HUA)in overweight or obese children and adolescents with depressive disorder.Method:196 children and adolescents hospitalized in Fuyang Third People's Hospital from January 2020 to December 2021 who met the diagnostic criteria of depression disorder according to the international classification of diseases(10th edition)were enrolled.General demographic data and clinical data were collected.Correlation and logistic regression analysis was used to investigate the serum uric acid level,HUA and its related factors in patients with depressive disorder.Results:The prevalence of HUA in overweight or obese adolescents with depressive disorder was 35.20%(69/196).HUA was associated with hospitalizations,body mass index(BMI)level,total cholesterol,low density lipoprotein cholesterol,creatinine,suicidal ideation,and antidepressant types(all P<0.05).Regression analysis indicated that high BMI,serum creatinine and suicidal ideation were independent risk factors for HUA in overweight or obese adolescents with depressive disorder(all P<0.05).Conclusion:The prevalence of HUA is higher in overweight or obese children and adolescents with depressive disorder,which is closely related to high BMI,serum creatinine and suicidal ideation.

关 键 词：儿童青少年 抑郁障碍 超重 肥胖 高尿酸血症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]