维吾尔族与汉族精神分裂症患者阿立哌唑治疗前后血清神经营养因子水平与疗效、认知功能的相关性  

The correlation between serum neurotrophin factor levels with curative effect and cognitive function in Uygur and Han schizophrenics before and after aripiprazole treatment

作　　者：马瑞晨[1] 梁路[2] 马燕娟[1] MA Rui-chen;LIANG Lu;MA Yan-juan(Department of Psychiatric,The Fourth People's Hospital of Urumqi,Urumqi 830002,China)

机构地区：[1]乌鲁木齐市第四人民医院精神科,830002 [2]乌鲁木齐市第四人民医院精神活性物质依赖科

出　　处：《临床精神医学杂志》2025年第2期129-133,共5页Journal of Clinical Psychiatry

基　　金：乌鲁木齐市科学技术计划项目(Y161310016)。

摘　　要：目的:探讨维吾尔、汉族精神分裂症患者阿立哌唑治疗前后血清脑源性神经营养因子(brain-derived neurotrophin factor,BDNF)、胶质细胞源性神经营养因子(glial cell derived neurotrophin factor,GDNF)水平与疗效、认知功能的相关性。方法:选择2021年6月至2022年12月乌鲁木齐市第四人民医院给予阿立哌唑治疗的80例维吾尔族精神分裂症患者(维吾尔族组)、80例汉族精神分裂症患者(汉族组),以及80名健康体检者(对照组)。利用双抗夹心法检测血清BDNF、GDNF水平,Pearson法分析相关性。结果:维吾尔族组、汉族组治疗前血清BDNF、GDNF水平均低于对照组(P均<0.05)。与治疗前相比,维吾尔族组、汉族组治疗后血清BDNF、GDNF水平均升高(P均<0.05)。与治疗前相比,维吾尔族组和汉族组治疗后阳性与阴性症状量表(positive and negative syndrome scale,PANSS)各项评分均降低(P均<0.05),认知功能评分中的语言流畅性、Stroop单词测验、连线测验、持续操作、空间广度及颜色测验评分均升高(P均<0.05)。相关性分析显示,治疗前后维吾尔族组和汉族组患者血清中BDNF、GDNF水平均与PANSS总评分有明显负相关(P均<0.05),与Stroop单词测验、语言流畅性、连线测验、持续操作均呈正相关(P均<0.05)。结论:维吾尔族与汉族精神分裂症患者治疗后血清BDNF、GDNF水平升高,且与阿立哌唑疗效及认知功能相关,检测BDNF、GDNF变化有助于评估认知功能损害程度及预后。Objective:To investigate the correlation between the serum levels of brain-derived neurotrophin factor(BDNF),glial cell derived neurotrophin factor(GDNF)with curative effect and cognitive function in Uygur and Han schizophrenics before and after aripiprazole treatment.Method:Eighty Uyghur schizophrenics patients(Uyghur group),80 Han schizophrenics patients(Han group)reated with aripiprazole,and 80 healthy individuals(control group)in the Fourth People's Hospital of Urumqi from June 2021 to December 2022 were selected.The double antibody sandwich method was applied to detect serum BDNF and GDNF levels.Pearson method was applied to analyze correlation.Results:The levels of serum BDNF,GDNF in the Uyghur and Han groups before treatment were lower than those in the control group(all P<0.05).Compared with before treatment,the serum levels of BDNF,GDNF in the Uyghur and Han groups increased after treatment(all P<0.05).Compared with before treatment,the positive and negative syndrome scale(PANSS)scores of the Uyghur and Han groups decreased after treatment(all P<0.05),while the language fluency,Stroop word test,connectivity test,continuous operation,spatial breadth,and color test in cognitive function scores increased(all P<0.05).Correlation analysis showed that the levels of BDNF and GDNF in the serum of Uyghur and Han patients before and after treatment were obviously negatively correlated with the total PANSS score(all P<0.05),and positively correlated with Stroop word test,language fluency test,wiring test,and continuous operation(all P<0.05).Conclusion:After treatment,the serum levels of BDNF and GDNF in Uyghur and Han schizophrenics patients increase,which is related to the efficacy of aripiprazole and cognitive function.Detecting changes in BDNF and GDNF can help evaluate the degree of cognitive impairment and prognosis.

关 键 词：精神分裂症 脑源性神经营养因子 胶质细胞源性神经营养因子 认知功能 治疗效果 

分 类 号：R749.3[医药卫生—神经病学与精神病学]