精神分裂症患者迟发性运动障碍基因多态性的研究进展  

Research progress of tardive dyskinesia gene polymorphism in schizophrenia

作　　者：鲁成好 李申[1] 张晓菲[1] 王丽莉[1] LU Cheng-hao;LI Shen;ZHANG Xiao-fei;WANG Li-li(Institute of Mental Health,Tianjin Anding Hospital,Mental Health Center of Tianjin Medical University,Tianjin 300222,China)

机构地区：[1]天津医科大学精神卫生中心,天津市安定医院,300222

出　　处：《临床精神医学杂志》2025年第2期154-157,共4页Journal of Clinical Psychiatry

基　　金：国家自然科学基金青年项目(81801323);天津市卫生健康科技项目(ZC20135)。

摘　　要：迟发性运动障碍(tardive dyskinesia,TD)是精神分裂症患者长期使用抗精神病药后引发的锥体外系不良反应,大大增加了患者的疾病复发率和死亡率。遗传因素对于TD的发生发展不容忽视,目前报道较多的相关易感基因包括DRD2,DRD3,COMT,SLC18A2,HTR2A和HTR2C等,但大多数单核苷酸多态性位点在不同的种群研究中未得到一致的结果。因此,本文系统归纳TD遗传学研究的关键方向与争议,为解析TD发生机制及个体化用药提供更加准确的理论线索。Tardive dyskinesia(TD),an extrapyramidal side effect induced by long-term antipsychotic use in schizophrenia patients,significantly increases the risk of disease relapse and mortality.Genetic factors play a critical role in TD pathogenesis,with reported susceptibility genes including DRD2,DRD3,COMT,SLC18A2,HTR2A,and HTR2C.However,most single nucleotide polymorphisms show inconsistent associations across population studies.Therefore,this paper systematically summarizes the key directions and controversies in the genetic research of TD,providing more accurate theoretical insights for understanding the mechanisms of TD and individualized medication strategies.

关 键 词：精神分裂症 迟发性运动障碍 易感基因 单核苷酸多态性 

分 类 号：R749.3[医药卫生—神经病学与精神病学]