丁苯酞序贯疗法对ACI患者神经功能、血液流变学指标及侧支循环的改善效果  

Improvement Effect of Butylphthalide Sequential Therapy on Neurological Function,Hemorheological Indicators,and Collateral Circulation in Patients with Acute Cerebral Infarction

作　　者：王瑞芳 WANG Ruifang(Linzhou People's Hospital,Anyang 456550,China)

机构地区：[1]林州市人民医院,河南安阳456550

出　　处：《延边大学医学学报》2025年第3期114-117,共4页Journal of Medical Science Yanbian University

摘　　要：目的:探讨丁苯酞序贯疗法对急性脑梗死(ACI)患者神经功能、血液流变学指标及侧支循环的改善效果。方法:进行回顾性研究,选择2023年4月至2024年4月医院收治的110例ACI患者作为研究对象,根据治疗方法分组,分为对照组(n=55)和观察组(n=55)。对照组采用溶栓联合常规丁苯酞治疗,观察组在溶栓联合常规丁苯酞治疗基础上采用丁苯酞序贯疗法。统计并比较两组治疗前、治疗4周时神经功能、血液流变学指标及侧支循环情况。结果:治疗4周时两组神经功能优于治疗前,观察组神经功能优于对照组(P<0.05);治疗4周时两组全血高切黏度、全血低切黏度、红细胞比容、纤维蛋白原(FIB)水平低于治疗前,观察组上述指标低于对照组(P<0.05);治疗4周时两组侧支循环改善优于治疗前,观察组侧支循环改善优于对照组(P<0.05)。结论:丁苯酞序贯疗法可有效促进ACI患者神经功能恢复,提高脑组织血流量,改善血液流变学指标,增强侧支循环功能。Objective:To investigate the improvement effect of butylphthalide sequential therapy on neurological function,hemorheological indicators,and collateral circulation in patients with acute cerebral infarction(ACI).Methods:A retrospective study was conducted,selecting 110 ACI patients admitted to the hospital from April 2023 to April 2024.Patients were divided into a control group(n=55)and an observation group(n=55)based on treatment methods.The control group received thrombolysis combined with conventional butylphthalide therapy,while the observation group received thrombolysis combined with conventional butylphthalide therapy plus butylphthalide sequential therapy.Neurological function,hemorheological indicators,and collateral circulation were statistically analyzed and compared between the two groups before treatment and after 4 weeks of treatment.Results:After 4 weeks of treatment,neurological function in both groups improved compared to pre-treatment levels,with the observation group showing superior improvement to the control group(P<0.05).At 4 weeks,whole blood high-shear viscosity,whole blood low-shear viscosity,hematocrit,and fibrinogen(FIB)levels in both groups were lower than pre-treatment values,with the observation group exhibiting lower levels than the control group(P<0.05).Collateral circulation improvement in both groups was superior to pre-treatment levels,with the observation group demonstrating greater improvement than the control group(P<0.05).Conclusion:Butylphthalide sequential therapy effectively promotes neurological function recovery,increases cerebral blood flow,improves hemorheological indicators,and enhances collateral circulation function in ACI patients.

关 键 词：急性脑梗死 丁苯酞序贯疗法 神经功能 血液流变学指标 侧支循环 

分 类 号：R743[医药卫生—神经病学与精神病学]