放疗在可切除胃癌术前治疗中的应用现状与思考  

Current status and reflection on radiotherapy in preoperative treatment of resectable gastric cancer

作　　者：何显力 高鹏 王楠 He Xianli;Gao Peng;Wang Nan(Department of General Surgery,Second Affiliated Hospital of Air Force Medical University,Xi′an 710038,China)

机构地区：[1]空军军医大学第二附属医院普通外科,西安710038

出　　处：《中华消化外科杂志》2025年第3期326-331,共6页Chinese Journal of Digestive Surgery

基　　金：陕西省创新能力支撑计划(2024RS-CXTD-82);空军军医大学第二附属医院临床研究重点项目(2021LCYJ020)。

摘　　要：放疗在胃癌治疗领域的应用取得成效。随着一系列临床研究结果的公布,学界针对胃癌术前治疗中是否应用放疗以及治疗方案存在争议。笔者通过阐述放疗的抗肿瘤生物学机制,回顾放疗在可切除胃癌术前治疗中的研究现状以及存在的问题,对胃癌新辅助放疗未来的发展趋势进行展望并提出思考。笔者相信通过多学科的融合和技术的进步,能够推动胃癌放疗理念的更新,实现放疗的精准化和个体化,从而为胃癌患者提供更加确切的生存获益。Radiotherapy has demonstrated certain efficacy in the treatment of gastric cancer.With the publication of a series of clinical studies,debates have arisen within the academic community regarding whether and how to apply radiotherapy in the preoperative treatment of gastric cancer.The authors elaborate on the anti‑tumor biological mechanisms of radiotherapy,review the current research status of radiotherapy in preoperative treatment of resectable gastric cancer,and analyze existing challenges to explore future trends in neoadjuvant radiotherapy for gastric cancer and propose reflections on related issues.Through multidisciplinary integration and technological advancements,it is anticipated that the conceptual framework of radiotherapy for gastric cancer will evolve,achieving precision and individualization in radiotherapy to provide patients with more definitive survival benefits.

关 键 词：胃肿瘤 可切除 术前治疗 放疗 化疗 免疫治疗 

分 类 号：R735.2[医药卫生—肿瘤]