三级淋巴结构在胃癌等多种肿瘤评估及治疗中的研究进展  

Research progress of tertiary lymphoid structures in evaluation and treatment of gastric cancer and other tumors

作　　者：武子镇 李晨 叶颖江[1] 王杉[1] 姜可伟[1] Wu Zizhen;Li Chen;Ye Yingjiang;Wang Shan;Jiang Kewei(Department of Gastrointestinal Surgery,Laboratory of Surgical Oncology,Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research,Peking University People′s Hospital,Beijing 100044,China)

机构地区：[1]北京大学人民医院胃肠外科外科肿瘤研究室结直肠癌诊疗研究北京市重点实验室,北京100044

出　　处：《中华消化外科杂志》2025年第3期401-406,共6页Chinese Journal of Digestive Surgery

基　　金：国家自然科学基金(52372262)。

摘　　要：三级淋巴结构(TLSs)作为肿瘤微环境的关键组成部分,近年来在肿瘤研究领域备受关注。TLSs由多种免疫细胞构成,在慢性炎症刺激下形成,成熟过程分为不同阶段。其通过模拟次级淋巴器官功能,产生适应性免疫应答发挥抗肿瘤作用。在胃癌预后方面,TLSs的细胞成分、空间分布及其与其他指标联合,均有助于预测患者预后。同时,TLSs评分系统有望成为评估免疫治疗效果的指标。诱导TLSs形成的治疗策略在动物模型中已取得一定成果,但仍需关注其潜在治疗风险。笔者聚焦于TLSs形成和成熟过程、抗肿瘤作用机制及其在胃癌及多种肿瘤中的预后评估和免疫治疗预测中的价值,以及诱导TLSs形成的治疗策略。Tertiary lymphoid structures(TLSs),as a crucial component of the tumor microenvironment,have attracted significant attention in the field of tumor research in recent years.TLSs are composed of multiple immune cells and formed under the stimulation of chronic inflammation,with their maturation process divided into different stages.They exert anti‐tumor effects by mimicking the functions of secondary lymphoid organs and generating adaptive immune responses.In terms of the prognosis of gastric cancer,the cell composition,spatial distribution of TLSs,and their combination with other indicators are all helpful in predicting the prognosis of patients.Meanwhile,the TLSs scoring system is expected to become an index for evaluating the efficacy of immunotherapy.Treatment strategies for inducing TLSs formation have achieved certain results in animal models,but potential treatment risks require attention.The authors elaborate on formation and maturation process of TLSs,anti‐tumor mechanism,value in prognostic assessment of gastric cancer and multiple tumors,prediction of immunotherapy,as well as treatment strategies for inducing the formation of TLSs.

关 键 词：胃肿瘤 三级淋巴结构 肿瘤微环境 预后 免疫治疗 

分 类 号：R735.2[医药卫生—肿瘤]