血清C反应蛋白与白蛋白比值评估胃癌患者预后的临床价值  

Clinical value of the ratio of serum C-reactive protein to albumin in evaluating the prognosis of patients with gastric cancer

作　　者：王义东 张玲 WANG Yidong;ZHANG Ling(Department of Oncology,Affiliated Jintan Hospital,Jiangsu University,Changzhou 213200,CHINA)

机构地区：[1]江苏大学附属金坛医院肿瘤科,江苏常州213200

出　　处：《江苏医药》2025年第3期297-299,共3页Jiangsu Medical Journal

摘　　要：目的探讨血清C反应蛋白与白蛋白比值(CAR)评估胃癌患者预后的临床价值。方法回顾性分析40例胃癌患者的临床资料。根据治疗前CAR中位数,将胃癌患者分为高CAR组(CAR>0.15,20例)和低CAR组(CAR≤0.15,20例),比较两组患者无进展生存期(PFS)和总生存期(OS)差异,采用单因素和多因素Cox回归分析CAR对胃癌患者预后的影响。结果高CAR组患者的中位PFS低于低CAR组(6.2个月vs.11.3个月)(P<0.05),中位OS亦低于低CAR组(10.5个月vs.18.7个月)(P<0.05)。多因素Cox回归分析显示,肿瘤分期Ⅳ期、姑息治疗方式和CAR升高均是胃癌患者PFS和OS的独立危险因素(P<0.05)。结论CAR升高提示胃癌患者预后较差。CAR可作为评估胃癌患者预后的生物学指标。Objective To explore the clinical value of the ratio of serum C-reactive protein to albumin(CAR)in evaluating the prognosis of the patients with gastric cancer.Methods Clinical data of 40 patients with gastric cancer were retrospectively analyzed.According to the median CAR before treatment,the patients were divided into two groups of HC(CAR>0.15,20 cases)and LC(CAR≤0.15,20 cases).The differences in progression-free survival(PFS)and overall survival(OS)were compared between the two groups.The effect of CAR on the outcome of patients was analyzed by univariate and multivariate Cox regression.Results The median PFS in group HC was significantly lower than that in group LC(6.2 months vs.11.3 months)(P<0.05),so did the median OS(10.5 months vs.18.7 months)(P<0.05).Multivariate Cox regression analysis showed that TNM at stageⅣ,palliative treatment and increased CAR were the independent risk factors for PFS and OS in the patients with gastric cancer(P<0.05).Conclusion An increased CAR in the patients with gastric cancer predicts a poor prognosis.CAR can be used as a biological index to predict the prognosis of the patients with gastric cancer.

关 键 词：C反应蛋白 白蛋白 胃癌 生存期 预后 

分 类 号：R735[医药卫生—肿瘤]